ArticleInfluenza and other respiratory viruses2021
Human post-infection serological response to the spike and nucleocapsid proteins of SARS-CoV-2.
Article in Influenza and other respiratory viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- COVID-19-vaccinated plasma treatment for COVID-19 patients?Influenza and other respiratory viruses · 2021Article
- Comparative Assessment of Sera from Individuals after S-Gene RNA-Based SARS-CoV-2 Vaccination with Spike-Protein-Based and Nucleocapsid-Based Serological Assays.Diagnostics (Basel, Switzerland) · 2021Article
- Human post-infection serological response to the spike and nucleocapsid proteins of SARS-CoV-2.Influenza and other respiratory viruses · 2021Article
- Serum Metabolic Profile in Patients With Long-Covid (PASC) Syndrome: Clinical Implications.Frontiers in medicine · 2021Article
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Authors and funding
21 authors.
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Abstract
To inform seroepidemiological studies, we characterized the IgG- responses in COVID-19 patients against the two major SARS-CoV-2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 COVID-19 sera collected up to 85 days post-symptom onset and 230 non-COVID-19 sera, including 27 SARS sera from 2003. Although the average SARS-CoV-2 S and N-IgG titers were comparable, N-responses were more variable among individuals. S- and N-assay specificity tested with non-COVID-19 sera were comparable at 97.5% and 97.0%, respectively. Therefore, S will make a better target due to its lower cross-reactive potential and its' more consistent frequency of detection compared to N.
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