ArticleThoracic cancer2020
Clinical characteristics of resected solitary ground-glass opacities: Comparison between benign and malignant nodules.
Article in Thoracic cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Decoding Malignant Lung Ground Glass Opacities: A Radiologic-Pathologic Study From Pure to Semi-Solid Lesions.Thoracic cancer · 2026Article
- Enhanced Malignancy Prediction of Small Lung Nodules in Different Populations Using Transfer Learning on Low-Dose Computed Tomography.Diagnostics (Basel, Switzerland) · 2025Article
- Enhanced management strategy of synchronous percutaneous biopsy and microwave ablation in patients with lung ground-glass opacities undergoing antithrombotic treatment: a clinical perspective on our experience.Frontiers in oncology · 2025Article
- Safety and efficacy of percutaneous biopsy and microwave ablation in patients with pulmonary nodules on antithrombotic therapy: A study with rivaroxaban bridging.Thoracic cancer · 2024Article
- Diagnostic accuracy of low-dose dual-input computed tomography perfusion in the differential diagnosis of pulmonary benign and malignant ground-glass nodules.Scientific reports · 2024Article
- Different clinicopathological features between young and older patients with pulmonary adenocarcinoma and ground-glass opacity.Scientific reports · 2024Article
- Bubble-like lucency in pulmonary ground glass nodules on computed tomography: a specific pattern of air-containing space for diagnosing neoplastic lesions.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Quantitative evaluation of density variability in the lesion-lung boundary zone to differentiate pulmonary subsolid nodules.Quantitative imaging in medicine and surgery · 2023Article
- Potential Role of Intrapulmonary Concomitant Lesions in Differentiating Non-Neoplastic and Neoplastic Ground Glass Nodules.Journal of inflammation research · 2023Article
- Correlations Between Inflammatory Cell Infiltration and Relative Density and the Boundary Manifestation of Pulmonary Non-Neoplastic Ground Glass Nodules.Journal of inflammation research · 2023Article
- Differential diagnosis of benign and malignant patchy ground-glass opacity by thin-section computed tomography.BMC cancer · 2022Article
- A Machine-Learning Approach to Developing a Predictive Signature Based on Transcriptome Profiling of Ground-Glass Opacities for Accurate Classification and Exploring the Immune Microenvironment of Early-Stage LUAD.Frontiers in immunology · 2022Article
- Significance of intra-nodular vessel sign in differentiating benign and malignant pulmonary ground-glass nodules.Insights into imaging · 2021Article
- Circulating tumor cells with epithelial-mesenchymal transition markers as potential biomarkers for the diagnosis of lung cancer.World journal of clinical cases · 2021Article
- Genomic landscape of ground glass opacities (GGOs) in East Asians.Journal of thoracic disease · 2021Article
- The Value of Topological Radiomics Analysis in Predicting Malignant Risk of Pulmonary Ground-Glass Nodules: A Multi-Center Study.Technology in cancer research & treatmentArticle
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe management of ground-glass opacities (GGOs) depends mainly on personal experience. In clinical practice, benign GGOs are not rare in resected specimens, for which operations may be avoided. We retrospectively compared the clinical features of resected GGOs to identify differential diagnostic characteristics.
methodsAmong 1456 patients with suspected malignant GGOs who underwent surgical resection, 105 patients (35 with benign GGOs and 70 matched controls with malignant GGOs) were included. Clinical characteristics, including demographics and radiologic, surgical and pathologic characteristics, were collected.
resultsThe smoking index (P = 0.044), frequency of coughing (P = 0.026), GGO size (P = 0.003), size change during follow-up (P = 0.011), location (P = 0.022), presence of air bronchogram sign (P = 0.004), distance to the pleura (P = 0.021) and positron emission tomography/computed tomography (PET/CT) appearance (P = 0.003) showed significant differences between the benign and malignant groups. Pathologically, the resected benign GGOs included focal fibrosis (17), inflammation or infection (seven), lymphoproliferative disorder (one), hamartoma (three), inflammatory myofibroblastic tumor (two), hemangioma or vascular malformation (two), endometriosis (two) and pulmonary cyst (one).
conclusionsA higher smoking index, coughing, larger size, similar or increased size during follow-up, location in the upper and middle lobes, air bronchogram sign on CT, lesion margin to pleura distance over 1 cm, and malignant tendency on PET/CT reports were associated with malignant GGOs. Relatively active surgical interventions could be considered for GGOs highly suspected of malignancy.
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