Evidence map›Paper›PMID 32844569›Full record

ArticleChemical biology & drug design2021

Novel phenolic antimicrobials enhanced activity of iminodiacetate prodrugs against biofilm and planktonic bacteria.

Danica J Walsh, Tom Livinghouse, Greg M Durling, Adrienne D Arnold, Whitney Brasier, Luke Berry, Darla M Goeres, Philip S Stewart

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical biology & drug design, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Role of RNAIII in Resistance to Antibiotics and Antimicrobial Agents inInternational journal of molecular sciences · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Danica J WalshChemistry and Biochemistry, Montana State University, Bozeman, MT, USA.ORCID 0000-0002-5509-1224
Tom LivinghouseChemistry and Biochemistry, Montana State University, Bozeman, MT, USA.
Greg M DurlingChemistry and Biochemistry, Montana State University, Bozeman, MT, USA.
Adrienne D ArnoldCenter for Biofilm Engineering, Montana State University, Bozeman, MT, USA.
Whitney BrasierCenter for Biofilm Engineering, Montana State University, Bozeman, MT, USA.
Luke BerryChemistry and Biochemistry, Montana State University, Bozeman, MT, USA.
Darla M GoeresCenter for Biofilm Engineering, Montana State University, Bozeman, MT, USA.
Philip S StewartCenter for Biofilm Engineering, Montana State University, Bozeman, MT, USA.

Funding

Stereoselective Heterocycle Synthesis via Zn(II) Promoted Metalloamination/CyclizationR01GM116949 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI LIVINGHOUSE, THOMAS STUART · 2016 to 2019
$607k
NIGMS NIH HHS R01 GM116949
6 · The paper itself

Abstract

Prodrugs are pharmacologically attenuated derivatives of drugs that undergo bioconversion into the active compound once reaching the targeted site, thereby maximizing their efficiency. This strategy has been implemented in pharmaceuticals to overcome obstacles related to absorption, distribution, and metabolism, as well as with intracellular dyes to ensure concentration within cells. In this study, we provide the first examples of a prodrug strategy that can be applied to simple phenolic antimicrobials to increase their potency against mature biofilms. The addition of (acetoxy)methyl iminodiacetate groups increases the otherwise modest potency of simple phenols. Biofilm-forming bacteria exhibit a heightened tolerance toward antimicrobial agents, thereby accentuating the need for new antibiotics as well as those, which incorporate novel delivery strategies to enhance activity toward biofilms.

Indexed as

Anti-Infective AgentsBiofilmsImino AcidsMicrobial Sensitivity TestsPhenolsProdrugsPseudomonas aeruginosaStaphylococcus epidermidisStructure-Activity RelationshipAnti-Infective AgentsImino Acidsiminodiacetic acidPhenolsProdrugsanti-biofilmantimicrobialdrug-conjugatepro-drugs

Identifiers

PMID32844569
PMCPMC7821224

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.