ArticleThe FEBS journal2021
Oral bacteria and leaky endothelial junctions in remote extraoral sites.
Article in The FEBS journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Host-pathogen interactions in periodontitis: an integrative interkingdom perspective.Frontiers in immunology · 2026Review
- Combination of Neovestitol and Vestitol Modifies the Profile of Periodontitis-Related Subgingival Multispecies Biofilm.Biomedicines · 2024Article
- Targeted proteomics in a population-based study identifies serum PECAM-1 and TRIM21 as inflammation markers for periodontitis.Clinical oral investigations · 2023Article
- RhoA/ROCK1 regulates the mitochondrial dysfunction through Drp1 induced by Porphyromonas gingivalis in endothelial cells.Journal of cellular and molecular medicine · 2023Article
- Antimicrobial activity of Desplac® oral gel in the subgingival multispecies biofilm formation.Frontiers in microbiology · 2023Article
- Gene Correlation Network Analysis to Identify Biomarkers of Peri-Implantitis.Medicina (Kaunas, Lithuania) · 2022Article
- Exacerbation of AMD Phenotype in Lasered CNV Murine Model by Dysbiotic Oral Pathogens.Antioxidants (Basel, Switzerland) · 2021Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Periodontitis and periodontal pathogens have been associated with systemic complications that influence comorbid conditions, such as cardiovascular disease. Using a zebrafish larvae infection model, Farrugia et al. show that Porphyromonas gingivalis causes vascular damage and increased endothelial permeability by degrading, via its gingipain proteases, platelet endothelial cell adhesion molecule-1, and vascular endothelial cadherin, which are crucial for endothelial junctional integrity. These findings suggest a molecular mechanism whereby this oral pathogen may contribute to endothelial dysfunction and perhaps atherosclerotic cardiovascular disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.