Evidence map›Paper›PMID 32844295›Full record

ArticleNeurochemical research2020

Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice.

Misa Nishiyama, Noritaka Nakamichi, Tomoyuki Yoshimura, Yusuke Masuo, Tomoe Komori, Takahiro Ishimoto, Jun-Ichi Matsuo, Yukio Kato

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Modern Analytical Techniques in Epilepsy Research.International journal of molecular sciences · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Drug metabolism and disposition: the biological fate of chemicals · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Misa NishiyamaFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.ORCID http://orcid.org/0000-0003-0207-6933
Noritaka NakamichiFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan. nakamichi@takasaki-u.ac.jp.ORCID http://orcid.org/0000-0002-0283-3546
Tomoyuki YoshimuraFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.ORCID http://orcid.org/0000-0002-6931-1048
Yusuke MasuoFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.ORCID http://orcid.org/0000-0003-1820-3749
Tomoe KomoriFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
Takahiro IshimotoFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.ORCID http://orcid.org/0000-0002-4799-7763
Jun-Ichi MatsuoFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.ORCID http://orcid.org/0000-0003-3667-7657
Yukio KatoFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.ORCID http://orcid.org/0000-0001-8135-5679
Kanazawa University · JP

Funding

Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan 15H04664Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan 19K07126
6 · The paper itself

Abstract

Understanding of the underlying mechanism of epilepsy is desired since some patients fail to control their seizures. The carnitine/organic cation transporter OCTN1/SLC22A4 is expressed in brain neurons and transports food-derived antioxidant ergothioneine (ERGO), L-carnitine, and spermine, all of which may be associated with epilepsy. This study aimed to clarify the possible association of this transporter with epileptic seizures. In both pentylenetetrazole (PTZ)-induced acute seizure and kindling models, ocnt1 gene knockout mice (octn1

Indexed as

AnimalsAntioxidantsBrain-Derived Neurotrophic FactorCytoskeletal ProteinsEpilepsyErgothioneineGene Knockout TechniquesHEK293 CellsHumansMaleMice, Inbred C57BLNerve Tissue ProteinsOrganic Cation Transport ProteinsPentylenetetrazolePiperidinesSeizuresactivity regulated cytoskeletal-associated proteinAntioxidantsBdnf protein, mouseBrain-Derived Neurotrophic FactorCytoskeletal ProteinsErgothioneineNerve Tissue ProteinsOrganic Cation Transport ProteinsPentylenetetrazolePiperidinesSlc22a4 protein, mouseSymportersXenobioticsEpilepsyErgothioneineMetabolomicsPentylenetetrazoleSeizureSlc22a4

Identifiers

PMID32844295
OpenAlexW3080762187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.