Observational studyPediatric nephrology (Berlin, Germany)2021
Be aware of acute kidney injury in critically ill children with COVID-19.
Observational study in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Epidemiology and clinical features of SARS-CoV-2 infection in children and adolescents in the pre-Omicron era: A global systematic review and meta-analysis.Journal of global health · 2024Pooled it
- Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit.Pediatric nephrology (Berlin, Germany) · 2021Pooled it
- Acute kidney injury outcomes in covid-19 patients: systematic review and meta-analysis.Jornal brasileiro de nefrologiaPooled it
- Retrospective evaluation of acute kidney injury in paediatric COVID-19 patients: a tertiary referral hospital experience.Journal of nephrology · 2024Observational
- Acute kidney injury in children with moderate-severe COVID-19 and multisystem inflammatory syndrome in children: a referral center experience.Pediatric nephrology (Berlin, Germany) · 2024Article
- Post-COVID-19 effect on biochemical parameters in children: Should we take heed?Saudi journal of biological sciences · 2023Article
- Impact of Negative Fluid Balance on Mortality and Outcome of Patients with Confirmed COVID-19.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Article
- COVID-19 and Severe Rhabdomyolysis Causing Acute Kidney Injury and Life-Threatening Hyperkalemia in a Pediatric Patient: a Case Report.SN comprehensive clinical medicine · 2023Article
- Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options.International immunopharmacology · 2022Review
- Intussusception and COVID-19 in Children: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2022Review
- Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions.Nature reviews. Nephrology · 2022Review
- Child with new onset nephrotic syndrome as the sole manifestation of SARS-CoV-2 infection.Journal of paediatrics and child health · 2022Article
- Role of therapeutic plasma exchange in the management of COVID-19-induced cytokine storm syndrome.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2022Review
- Renal manifestations of COVID 19 in children.Journal of family medicine and primary care · 2022Review
- Can microalbuminuria be an ındicator of renal ınvolvement in pediatric Covid 19 patients?Infection · 2022Article
- Acute Kidney Injury in Children with Acute Appendicitis.Children (Basel, Switzerland) · 2022Article
- Evaluation of Tubular Dysfunction Using Urine Biomarkers in Children with COVID-19.Turkish archives of pediatrics · 2022Article
- Acute kidney injury in COVID-19 pediatric patients in North America: Analysis of the virtual pediatric systems data.PloS one · 2022Article
- The overall impact of COVID-19 on healthcare during the pandemic: A multidisciplinary point of view.Health science reports · 2021Review
- [The position of children in the pandemic and the role of COVID-19 in their lives].Nephrologie & therapeutique · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAcute kidney injury (AKI) is a common complication of critically ill adult patients with COVID-19. However, currently, no studies investigate kidney impairment in children with COVID-19. We investigated incidence and treatment of AKI in pediatric patients with COVID-19 in Wuhan Children's Hospital during the early stages of the COVID-19 pandemic and discuss possible mechanisms of AKI related to SARS-CoV-2 infection.
methodsBy extracting data from electronic medical records, we conducted a retrospective observational study of kidney involvement in confirmed pediatric COVID-19 cases in Wuhan Children's Hospital during the coronavirus outbreak, from January 24 to March 20, 2020. Clinical presentations, clinical courses, laboratory findings, and medical interventions are described below.
resultsAmong 238 confirmed COVID-19 cases, only three were critically ill and needed intensive care unit (ICU) admission. All three developed AKI, but AKI was not detected in any non-critically ill patients outside the ICU. Two of the three patients with AKI had prodromal gastrointestinal symptoms. Significantly elevated interleukin-6 (IL-6) levels and complement activation were observed in these patients with AKI. The three patients with AKI were treated with plasma exchange (PE) and continuous kidney replacement therapy (CKRT), resulting in one complete recovery, one partial recovery, and one mortality due to critical illness.
conclusionsCritically ill children with COVID-19 may develop AKI, especially following prodromal gastrointestinal symptoms. An inflammatory storm and complement-mediated injury may underlie AKI development in children with COVID-19. Our study supports implantation of PE and CKRT in management of critically ill patients with AKI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.