ArticleCerebral cortex (New York, N.Y. : 1991)2021
Normative Analysis of Individual Brain Differences Based on a Population MRI-Based Atlas of Cynomolgus Macaques.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders.Neuroscience bulletin · 2026Review
- Convergent and Divergent Connectivity Patterns of the Arcuate Fasciculus in Macaques and Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Medical statistics education in the big data era: focusing on critical thinking and ethical competence.Frontiers in public health · 2026Article
- State-specific Regulation of Electrical Stimulation in the Intralaminar Thalamus of Macaque Monkeys: Network and Transcriptional Insights into Arousal.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Longitudinal mapping of the development of cortical thickness and surface area in rhesus macaques during the first three years.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys.Nature communications · 2023Article
- Population-Average Brain Templates and Application to Automated Voxel-Wise Analysis Pipelines for Cynomolgus Macaque.Neuroinformatics · 2022Article
- Article
- Automatic method for individual parcellation of manganese-enhanced magnetic resonance imaging of rat brain.Frontiers in neuroscience · 2022Article
- Depletion of giant ANK2 in monkeys causes drastic brain volume loss.Cell discovery · 2021Article
- Marmoset Brain Mapping V3: Population multi-modal standard volumetric and surface-based templates.NeuroImage · 2021Article
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Authors and funding
14 authors.
Funding
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Abstract
The developmental trajectory of the primate brain varies substantially with aging across subjects. However, this ubiquitous variability between individuals in brain structure is difficult to quantify and has thus essentially been ignored. Based on a large-scale structural magnetic resonance imaging dataset acquired from 162 cynomolgus macaques, we create a species-specific 3D template atlas of the macaque brain, and deploy normative modeling to characterize individual variations of cortical thickness (CT) and regional gray matter volume (GMV). We observed an overall decrease in total GMV and mean CT, and an increase in white matter volume from juvenile to early adult. Specifically, CT and regional GMV were greater in prefrontal and temporal cortices relative to early unimodal areas. Age-dependent trajectories of thickness and volume for each cortical region revealed an increase in the medial temporal lobe, and decreases in all other regions. A low percentage of highly individualized deviations of CT and GMV were identified (0.0021%, 0.0043%, respectively, P < 0.05, false discovery rate [FDR]-corrected). Our approach provides a natural framework to parse individual neuroanatomical differences for use as a reference standard in macaque brain research, potentially enabling inferences regarding the degree to which behavioral or symptomatic variables map onto brain structure in future disease studies.
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