ArticleClinical diabetes and endocrinology2020
Acromegaly: a clinical perspective.
Article in Clinical diabetes and endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Growth Hormone-Secreting Pituitary Macroadenoma: Diagnosis of Acromegaly in a Young Adult.Cureus · 2025Article
- Presence of cerebral microbleeds is associated with cognitive decline in acromegaly.Frontiers in oncology · 2022Article
- Serum insulin-like growth factor-1 concentrations in healthy cats before and after weight gain and weight loss.Journal of veterinary internal medicine · 2021Article
- Immunohistochemical evaluation of biomarkers with predictive role in acromegaly: a literature review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo examine the clinical and hormonal profiles, comorbidities, treatment patterns, surgical pathology and clinical outcomes of patients diagnosed with acromegaly at the Cleveland Clinic over a 15-year period.
methodsA retrospective chart review of patients with acromegaly who underwent surgical resection between 2003 and 2018.
resultsA total of 136 patients (62 men; mean age 48.1 years) with biochemical evidence of acromegaly were analyzed. Median insulin-like growth factor 1 (IGF-1) level at diagnosis was 769.0 ng/mL and most patients had a macroadenoma (82.2%). Immunoreactivity to growth hormone (GH) was noted in 124 adenomas, with co-staining in 89 adenomas. Complete visible tumor resection during initial surgery was achieved in 87 patients (64.0%). In this cohort, complete response to surgery alone was observed in 61 patients (70.1%), while 31 out of 65 patients (47.7%) who received additional post-surgical medications and/or radiation therapy achieved complete response. At most recent follow-up, 92 patients achieved eventual complete response by documented normalization of IGF-1 levels. Higher IGF-1 level at diagnosis (
conclusionIn this study, the majority of tumors were macroadenoma, plurihormonal, and treated effectively with surgery alone or surgery with adjuvant medical or radiation therapy. More studies are needed to identify additional molecular biomarkers, tumor characteristics and imaging findings to individualize treatment and better predict treatment outcomes.
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