ReviewTherapeutic advances in endocrinology and metabolism2020
Current understanding of hypothalamic amenorrhoea.
Review in Therapeutic advances in endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Association of psychosocial factors at work with fertility and menstrual disorders: A systematic review.Japan journal of nursing science : JJNS · 2025Pooled it
- Psychological factors in functional hypothalamic amenorrhea: A systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Menstrual cycles during COVID-19 lockdowns: A systematic review and meta-analysis.Frontiers in reproductive health · 2022Pooled it
- Empty Follicle Syndrome: Current Therapeutic Approaches and the Role of Triggering Agents in Assisted Reproductive Technology.Medical sciences (Basel, Switzerland) · 2026Review
- Molecular Mechanisms of Dysregulated LH and FSH Secretion in Human Reproductive Failure.Biomedicines · 2026Review
- Decoding menstrual health across the lifespan: a scoping review of digital health tools in research.medRxiv : the preprint server for health sciences · 2026Article
- [Neuroendocrine regulation of the reproductive system: integration of research of neuropeptide and experimental pathophysiology of amenorrhea of different genesis (literature review)].Problemy endokrinologii · 2026Review
- Decoding menstrual health across the lifespan: a scoping review of digital health tools in research.npj women's health · 2026Article
- Assessing Obstetrics and Gynecology (OBGYN) Clinicians' Knowledge, Practice, and Attitudes toward Anorexia Nervosa, Atypical Anorexia Nervosa, and Amenorrhea.Journal of pediatric and adolescent gynecology · 2025Article
- The neuroendocrine puzzle of epilepsy and infertility: what are we missing?Frontiers in neurology · 2025Review
- Frequency, clinical presentation and management of primary amenorrhea in a tertiary care setting.Pakistan journal of medical sciences · 2024Article
- Dietary and Lifestyle Management of Functional Hypothalamic Amenorrhea: A Comprehensive Review.Nutrients · 2024Review
- Associations of Early Prolonged Secondary Amenorrhea in Women With and Without HIV.Open forum infectious diseases · 2024Article
- Retrospective Analysis of Effective Management Strategies for Primary Amenorrhea of Reproductive Age in Saudi Arabia.Life (Basel, Switzerland) · 2024Article
- The impact of COVID-19 on menstrual cycle's alterations, in relation to depression and sleep disturbances: a prospective observational study in a population of medical students.BMC women's health · 2024Observational
- Comparing pregnancy and pregnancy outcome rates between adolescents with and without pre-existing mental disorders.PloS one · 2024Article
- Determinants and Assessment of Menstrual Blood Flow.Current epidemiology reports · 2023Article
- Article
- Review
- Functional Hypothalamic Amenorrhea: Recognition and Management of a Challenging Diagnosis.Mayo Clinic proceedings · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Hypothalamic amenorrhoea (HA) accounts for approximately 30% of cases of secondary amenorrhoea in women of reproductive age. It is caused by deficient secretion of hypothalamic gonadotrophin-releasing hormone, which in turn leads to failure of pituitary gonadotrophin and gonadal steroid release. Functional HA (FHA) is defined as HA occurring in the absence of a structural lesion and is predominantly caused by significant weight loss, intense exercise or stress. Treatment of FHA is crucial in avoiding the long-term health consequences on fertility and bone health, in addition to reducing psychological morbidity. This article summarises our understanding of the mechanisms underlying FHA, the evidence base for its clinical management and emerging therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.