ReviewWorld journal of cardiology2020
Comprehensive review of hemolysis in ventricular assist devices.
Review in World journal of cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Heparin-induced thrombocytopenia in patients with mechanical circulatory support: a systematic review and meta-analysis.Research and practice in thrombosis and haemostasis · 2026Pooled it
- Axial Flow Percutaneous Ventricular Assist Devices: Physiology, Procedural Considerations, and Clinical Applications-A State-of-the-Art Review.Structural heart : the journal of the Heart Team · 2026Review
- From Early Models to Emerging Trends: The Evolution of Computational Hemolysis Prediction.Annals of biomedical engineering · 2026Review
- Trial-Based Hemolysis Modeling to Investigate Operating Modes of Continuous-Flow LVADs.Artificial organs · 2026Article
- Chronic kidney disease following left ventricular assist device implantation: contemporary insights and future perspectives.Heart failure reviews · 2025Review
- Experimental Investigation of the Applicability of the Stress-Based and Strain-Based Hemolysis Models for Short-Term Stress Peaks Typical for Rotary Blood Pumps.Artificial organs · 2025Article
- Pump-Induced Hemolysis of Speed Modulated Axial-Flow Left Ventricular Assist Devices.Artificial organs · 2025Article
- Evaluation of hemolysis in patients supported with Impella 5.5: a single center experience.Journal of cardiothoracic surgery · 2025Article
- Patient-specific Predictors of Haemolysis with Percutaneous Ventricular Assist Devices.Cardiac failure review · 2025Article
- In vitro study on device-induced damage to blood cellular components and degradation of von Willebrand factor in a CentriMag pump-assisted circulation.Artificial organs · 2024Article
- [Progress in the analysis of hemolysis and coagulation models for interventional micro-axial flow blood pumps].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Computational fluid dynamics-based design and in vitro characterization of a novel pediatric pump-lung.Artificial organs · 2024Article
- Prevention of thrombus formation in blood pump by mechanical circular orbital excitation of impeller in magnetically levitated centrifugal pump.Artificial organs · 2023Article
- Comparison of the Hemocompatibility of an Axial and a Centrifugal Left Ventricular Assist Device in an In Vitro Test Circuit.Journal of clinical medicine · 2022Article
- Computational Fluid-Structure Interaction Study of a New Wave Membrane Blood Pump.Cardiovascular engineering and technology · 2022Article
- Extracorporeal membrane oxygenation-assisted emergency percutaneous treatment of left ventricular assist device graft occlusion.ESC heart failure · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ventricular assist devices (VADs) have played an important role in altering the natural history of end-stage heart failure. Low-grade hemolysis has been traditionally described in patients with VADs, indicating effective device functionality. However, clinically significant hemolysis could be crucial in terms of prognosis, calling for prompt therapeutic actions. The absence of solid and widely approved diagnostic criteria for clinically significant hemolysis, render the utilization of hemolysis laboratory markers challenging. Hemolysis incidence varies (5%-18%) depending on definition and among different VAD generations, being slightly higher in continuous-flow devices than in pulsatile devices. Increased shear stress of red blood cells and underlying device thrombosis appear to be the main pathogenetic pathways. No certain algorithm is available for the management of hemolysis in patients with VADs, while close clinical and laboratory monitoring remains the cornerstone of management. Imaging examinations such as echocardiography ramp test or computed tomography scan could play a role in revealing the underlying cause. Treatment should be strictly personalized, including either pharmacological (antithrombotic treatment) or surgical interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.