Evidence map›Paper›PMID 32843820›Full record

ArticleSensors and actuators. B, Chemical2020

Rapid Enrichment and Ultrasensitive Detection of Influenza A Virus in Human Specimen using Magnetic Quantum Dot Nanobeads Based Test Strips.

Zikun Bai, Hongjuan Wei, Xingsheng Yang, Yanhui Zhu, Yongjin Peng, Jing Yang, Chongwen Wang, Zhen Rong, Shengqi Wang

Open access · greenAbstract read
In one paragraph

Article in Sensors and actuators. B, Chemical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 77 citations in OpenAlex.

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  12. Mechanisms, Techniques and Devices of Airborne Virus Detection: A Review.International journal of environmental research and public health · 2023
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  20. Rapid detection of SARS-CoV-2: The gradual boom of lateral flow immunoassay.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zikun BaiBeijing Institute of Radiation Medicine, Beijing 100850, PR China.
Hongjuan WeiBeijing Institute of Radiation Medicine, Beijing 100850, PR China.
Xingsheng YangBeijing Institute of Radiation Medicine, Beijing 100850, PR China.
Yanhui ZhuBeijing Institute of Radiation Medicine, Beijing 100850, PR China.
Yongjin PengBeijing Institute of Radiation Medicine, Beijing 100850, PR China.
Jing YangBeijing Institute of Radiation Medicine, Beijing 100850, PR China.
Chongwen WangBeijing Institute of Radiation Medicine, Beijing 100850, PR China.
Zhen RongBeijing Institute of Radiation Medicine, Beijing 100850, PR China.
Shengqi WangBeijing Institute of Radiation Medicine, Beijing 100850, PR China.
Beijing Radiation Center · CNAnhui Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza A virus (IAV) possesses a high infectivity and pathogenicity, and can lead to severe respiratory infection with similar symptoms caused by some other common respiratory viruses. Lateral flow assay (LFA) has been widely deployed in remote settings as a rapid and reliable approach for point-of-care detection of infectious pathogens. However, it still remains challenging to detect IAV virions using LFA from clinical samples such as nasopharyngeal or throat swabs, because their various components and high viscosity can decrease flow velocity and lead to the nonspecific adsorption of nanoparticle labels on the sensing membrane. Herein, we demonstrated a magnetic quantum dot nanobeads (MQBs) based LFA for magnetic enrichment and fluorescent detection of IAV virions in clinical specimens. In this study, MQBs were synthesized and then conjugated with IAV-specific antibody to efficiently enrich IAV virions from complex biological matrix, but also serve as highly bright fluorescent probes in lateral flow strips. This assay can achieve quantitative detection of IAV virions with a low limit of detection down to 22 pfu mL

Indexed as

Influenza A virusLateral flow assayMagnetic enrichmentMagnetic quantum dot nanobeadNasopharyngeal swab

Identifiers

PMID32843820
PMCPMC7441045
OpenAlexW3081316950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.