Evidence map›Paper›PMID 32843721›Full record

ArticleOncogene2020

Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma.

Xiyin Wang, Jillian R H Wendel, Robert E Emerson, Russell R Broaddus, Chad J Creighton, Douglas B Rusch, Aaron Buechlein, Francesco J DeMayo, John P Lydon, Shannon M Hawkins

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  3. UterineCancers · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Xiyin WangDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-3642-9373
Jillian R H WendelDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA.
Robert E EmersonDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Russell R BroaddusDepartment of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Chad J CreightonDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6090-703X
Douglas B RuschCenter for Genomics and Bioinformatics, Indiana University, Bloomington, IN, USA.
Aaron BuechleinCenter for Genomics and Bioinformatics, Indiana University, Bloomington, IN, USA.
Francesco J DeMayoNational Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.
John P LydonDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Shannon M HawkinsDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA. shhawkin@iu.edu.ORCID http://orcid.org/0000-0002-0727-3971
Indiana University School of MedicineBaylor College of Medicine · USIndiana University Bloomington · USTriangle · USUniversity of North Carolina at Chapel Hill · US

Funding

Targeting the PI3K Signaling Pathway in Endometrial CarcinomaP50CA098258 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BROADDUS, RUSSELL R · 2003 to 2020
$32.0M
Environmental Signaling in Reproduction and PregnancyZIAES103311 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DEMAYO, FRANCESCO · 2016 to 2025
$30.5M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Intramural NIH HHS ZIA ES103311NCATS NIH HHS UL1 TR002529NCI NIH HHS P50 CA098258
6 · The paper itself

Abstract

Endometrial cancer remains the most common gynecological malignancy in the United States. While the loss of the tumor suppressor, PTEN (phosphatase and tensin homolog), is well studied in endometrial cancer, recent studies suggest that DICER1, the endoribonuclease responsible for miRNA genesis, also plays a significant role in endometrial adenocarcinoma. Conditional uterine deletion of Dicer1 and Pten in mice resulted in poorly differentiated endometrial adenocarcinomas, which expressed Napsin A and HNF1B (hepatocyte nuclear factor 1 homeobox B), markers of clear-cell adenocarcinoma. Adenocarcinomas were hormone-independent. Treatment with progesterone did not mitigate poorly differentiated adenocarcinoma, nor did it affect adnexal metastasis. Transcriptomic analyses of DICER1 deleted uteri or Ishikawa cells revealed unique transcriptomic profiles and global miRNA downregulation. Computational integration of miRNA with mRNA targets revealed deregulated let-7 and miR-16 target genes, similar to published human DICER1-mutant endometrial cancers from TCGA (The Cancer Genome Atlas). Similar to human endometrial cancers, tumors exhibited dysregulation of ephrin-receptor signaling and transforming growth factor-beta signaling pathways. LIM kinase 2 (LIMK2), an essential molecule in p21 signal transduction, was significantly upregulated and represents a novel mechanism for hormone-independent pathogenesis of endometrial adenocarcinoma. This preclinical mouse model represents the first genetically engineered mouse model of poorly differentiated endometrial adenocarcinoma.

Indexed as

Adenocarcinoma, Clear CellAnimalsCell DifferentiationCell Line, TumorDEAD-box RNA HelicasesDisease Models, AnimalEndometrial NeoplasmsEndometriumFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGene Knockout TechniquesHumansLim KinasesMiceMice, TransgenicDEAD-box RNA HelicasesDICER1 protein, humanDicer1 protein, mouseLimk2 protein, mouseLim KinasesMicroRNAsPTEN PhosphohydrolasePten protein, mouseRibonuclease III

Identifiers

PMID32843721
PMCPMC7541676
OpenAlexW3081353173

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.