ArticleScientific reports2020
Vitamin D ameliorates adipose browning in chronic kidney disease cachexia.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Skeletal muscle atrophy in clinical and preclinical models of chronic kidney disease: A systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- The Role of Vitamin D in Skeletal Muscle Repair and Regeneration in Animal Models and Humans: A Systematic Review.Nutrients · 2023Pooled it
- Thermogenic adipose tissue in older adults with obesity: a narrative review of mechanisms, brown fat resistance, and the translational relevance of exercise and nutrition.Frontiers in nutrition · 2026Review
- Nutritional Influences on Brown and Beige Adipocyte: Unraveling the Molecular Mechanisms and Metabolic Implications.Food science & nutrition · 2025Review
- Soluble alpha-klotho and 25-hydroxivitamin D are not associated with brown adipose tissue metabolism in young healthy adults.Journal of physiology and biochemistry · 2025Article
- Combating chronic kidney disease-associated cachexia: A literature review of recent therapeutic approaches.BMC nephrology · 2025Review
- HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis.Renal failure · 2024Article
- The Different Shades of Thermogenic Adipose Tissue.Current obesity reports · 2024Review
- Skeletal Muscle Injury in Chronic Kidney Disease-From Histologic Changes to Molecular Mechanisms and to Novel Therapies.International journal of molecular sciences · 2024Review
- Vitamin D and Sarcopenia in the Senior People: A Review of Mechanisms and Comprehensive Prevention and Treatment Strategies.Therapeutics and clinical risk management · 2024Review
- Interplay between Vitamin D and Adipose Tissue: Implications for Adipogenesis and Adipose Tissue Function.Nutrients · 2023Review
- Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance.Cardiovascular research · 2023Review
- Adipose tissue metabolic changes in chronic kidney disease.Immunometabolism (Cobham, Surrey) · 2023Review
- Growth Hormone Improves Adipose Tissue Browning and Muscle Wasting in Mice with Chronic Kidney Disease-Associated Cachexia.International journal of molecular sciences · 2022Article
- Interconnection between Cardiac Cachexia and Heart Failure-Protective Role of Cardiac Obesity.Cells · 2022Review
- Differential Effects of 25-Hydroxyvitamin DCells · 2021Article
- The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia.Scientific reports · 2021Article
- Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation.Stem cell research & therapy · 2021Article
- Update on the Crosstalk Between Adipose Tissue and Mineral Balance in General Population and Chronic Kidney Disease.Frontiers in pediatrics · 2021Review
- Association Between Secondary Hyperparathyroidism and Body Composition in Pediatric Patients With Moderate and Advanced Chronic Kidney Disease.Frontiers in pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 2 countries.
Wai W Cheung *Pediatric Nephrology, Rady Children's Hospital San Diego, University of California, San Diego, USA.
Wei Ding *Division of Nephrology, School of Medicine, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
Hal M HoffmanDepartment of Pediatrics, University of California, San Diego, USA.
Zhen WangDepartment of Pediatrics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
Sheng HaoDepartment of Nephrology and Rheumatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Ronghao ZhengDepartment of Pediatrics, Hubei Maternal and Child Health Hospital, Wuhan, China.
Alex GonzalezPediatric Nephrology, Rady Children's Hospital San Diego, University of California, San Diego, USA.
Jian-Ying ZhanChildren's Hospital, Zhejiang University, Hangzhou, China.
Ping ZhouDepartment of Pediatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.ORCID http://orcid.org/0000-0001-9680-1651
Shiping LiCollege of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.ORCID http://orcid.org/0000-0001-8732-7193
Mary C EsparzaDepartment of Orthopedic Surgery, University of California, San Diego, USA.
Richard L LieberShirley Ryan AbilityLab and Northwestern University, Chicago, USA.ORCID http://orcid.org/0000-0002-7203-4520
Robert H MakPediatric Nephrology, Rady Children's Hospital San Diego, University of California, San Diego, USA. romak@health.ucsd.edu.
University of California San Diego · USShanghai Jiao Tong University · CNChildren's Hospital of Zhejiang University · CNHarbin Medical University · CNHubei Provincial Women and Children's Hospital · CNNorthwestern University · USShanghai Ninth People's Hospital · CNYangzhou University · CN
Funding
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3MNational Center for Muscle Rehabilitation ResearchR24HD050837 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIEBER, RICHARD L., WARD, SAMUEL RICHARD · 2005 to 2014
$7.2MTargeting NLRP3 inflammasome for treating muscle complications of chronic kidney diseaseR01DK125811 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAK, ROBERT H · 2020 to 2022
$710kRR&D Senior Research Career Scientist Award ApplicationIK6RX003351 · VA · EDWARD HINES JR VA HOSPITAL · PI LIEBER, RICHARD L. · 2020 to 2025
–NCATS NIH HHS UL1 TR001442NICHD NIH HHS R24 HD050837NIDDK NIH HHS R01 DK125811RRD VA IK6 RX003351
Abstract
Patients with chronic kidney disease (CKD) are often 25(OH)D
Indexed as
Adipocytes, BeigeAdipocytes, BrownAdipocytes, WhiteAnimalsCachexiaCalcifediolCalcitriolDisease Models, AnimalEatingFibrosisGene Expression RegulationHand StrengthMiceMice, Inbred C57BLMuscle Fibers, SkeletalNephrectomyCalcifediolCalcitriolParathyroid HormoneRNA, Messenger
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.