Evidence map›Paper›PMID 32843670›Full record

ArticleScientific reports2020

Sensory satellite glial Gq-GPCR activation alleviates inflammatory pain via peripheral adenosine 1 receptor activation.

Alison Xiaoqiao Xie, Aric Madayag, Suzanne K Minton, Ken D McCarthy, Anna P Malykhina

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Transgenic Mouse Models to Study Enteric Glia.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Expression of Human Immunodeficiency Virus Transactivator of Transcription (HIV-TatJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2022
    Article
  10. Fibroblastic SMOC2 Suppresses Mechanical Nociception by Inhibiting Coupled Activation of Primary Sensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  11. Article
  12. Review
  13. Review
  14. Purines in Pain as a Gliopathy.Frontiers in pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alison Xiaoqiao XieDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, USA. alison.xie@cuanschutz.edu.
Aric MadayagDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, USA.
Suzanne K MintonDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, USA.
Ken D McCarthyProfessor Emeritus in the Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, 120 Mason Farm Road, 4010 Genetic Medicine Bldg, Campus Box 7365, Chapel Hill, NC, 27599-7365, USA.
Anna P MalykhinaDivision of Urology, Department of Surgery, University of Colorado Denver (UCD), Anschutz Medical Campus (AMC), 12700E 19th Ave., Room 6440D, Mail stop C317, Aurora, CO, 80045, USA.
University of North Carolina at Chapel Hill · USUniversity of Colorado Denver · US

Funding

Mechanisms of neurogenic bladder dysfunction in a viral murine model of multiple sclerosisR01DK116648 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MALYKHINA, ANNA P · 2020 to 2022
$1.0M
Role of Spinal Cord Lamina II Astrocytes in Neurophysiology and Chronic PainR01NS058904 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCCARTHY, KEN DOUGLAS · 2008 to 2010
$918k
Regulation of pelvic pain and micturition reflex by VEGF in urological chronic pelvic pain syndromeR01DK121506 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MALYKHINA, ANNA P · 2019 to 2021
$700k
NIDDK NIH HHS R01 DK116648NIDDK NIH HHS R01 DK121506NINDS NIH HHS R01 NS058904
6 · The paper itself

Abstract

Glial fibrillary acidic protein expressing (GFAP

Indexed as

AnimalsBenzilatesClozapineFreund's AdjuvantGenes, SyntheticGTP-Binding Protein alpha Subunits, Gq-G11Hot TemperatureHyperalgesiaInflammationMaleMiceMice, Inbred C57BLMice, TransgenicMuscarinic AgonistsNeurogliaNociception1,3-dipropyl-8-cyclopentylxanthine8-(3-sulfophenyl)theophyllineBenzilatesClozapineclozapine N-oxideFreund's AdjuvantGTP-Binding Protein alpha Subunits, Gq-G11Muscarinic AgonistsNortropanesPurinergic P1 Receptor AgonistsPurinergic P1 Receptor AntagonistsReceptor, Adenosine A1Receptor, Muscarinic M3Receptors, G-Protein-CoupledRecombinant Fusion ProteinsTheophyllinetrospium chlorideXanthines

Identifiers

PMID32843670
PMCPMC7447794
OpenAlexW3081482778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.