Evidence map›Paper›PMID 32843656›Full record

ArticleSignal transduction and targeted therapy2020

The first human trial of CRISPR-based cell therapy clears safety concerns as new treatment for late-stage lung cancer.

Shenghui He

Abstract readComment
In one paragraph

Article in Signal transduction and targeted therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. The Role of CRISPR and Its Therapeutic Applications in Glioblastoma.International journal of molecular sciences · 2026
    Review
  2. Review
  3. Review
  4. Gene Editing: Developments, Ethical Considerations, and Future Directions.Journal of community hospital internal medicine perspectives · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Germline stem cells in human.Signal transduction and targeted therapy · 2022
    Review
  9. Review
  10. Targeting Cancer with CRISPR/Cas9-Based Therapy.International journal of molecular sciences · 2022
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Precision Genome Engineering in Human Disease: Expanding Therapeutic Roles of CRISPR Technologies.Nigerian medical journal : journal of the Nigeria Medical Association
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Shenghui HeThe Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, 27599-7295, USA. shenghui@email.unc.edu.ORCID http://orcid.org/0000-0001-8842-7137

Funding

The Role of p16INK4 in Mammalian AgingR01AG024379 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HE, SHENGHUI · 2004 to 2019
$4.6M
NIA NIH HHS R01 AG024379
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsCell- and Tissue-Based TherapyClustered Regularly Interspaced Short Palindromic RepeatsFeasibility StudiesHumansT-Lymphocytes

Identifiers

PMID32843656
PMCPMC7447629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.