ArticleNature communications2020
Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 148 citations in OpenAlex.
- Crosstalk in the cold: host-microbe interactions in insect diapause.Annals of the Entomological Society of America · 2026Review
- A roadmap to key traits of invasive Drosophilidae.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Microbiome contribution tobioRxiv : the preprint server for biology · 2026Article
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- Lactobacilli biology, applications and host interactions.Nature reviews. Microbiology · 2026Review
- Substrate utilization and cross-feeding synergistically determine microbiome resistance to pathogen invasion.Nature ecology & evolution · 2026Article
- Tumour-host interactions in Drosophila: mechanisms in the tumour micro- and macroenvironment.Molecular oncology · 2026Review
- Phylosymbiosis and functional redundancy in the Drosophila (Diptera: Drosophilidae) gut microbiome and its implications for host fitness.Journal of insect science (Online) · 2026Article
- Article
- Cross-feeding-based rational design of a probiotic combination ofGut microbes · 2025Article
- Microbial metabolites as engines of behavioral variation across animals.Gut microbes · 2025Review
- Spatial segregation and cross-kingdom interactions drive stingless bee hive microbiome assembly.Nature communications · 2025Article
- The Gut Microbiota ofMicroorganisms · 2025Review
- Arbuscular Mycorrhizal Fungi as Core Engineers in Synthetic Microbial Communities: Boosting Plant Growth and Soil Health for Sustainable Agriculture.Journal of fungi (Basel, Switzerland) · 2025Review
- Is it time to assignApplied and environmental microbiology · 2025Article
- Environment and diet shape the geography-specificApplied and environmental microbiology · 2025Article
- Complex carbohydrate utilization by gut bacteria modulates host food consumption.Nature communications · 2025Article
- Effects of Different Net Energy Levels in Low-Protein Diversified Diets on Growth Performance, Nutrient Digestibility, Carcass Characteristics, Meat Quality, and Colonic Microbiota in Finishing Pigs.Animals : an open access journal from MDPI · 2025Article
- Polyunsaturated fatty acids promote appetite via the microbiome-gut-brain axis.bioRxiv : the preprint server for biology · 2025Article
- Gut microbiota-mediated lipid accumulation as a driver of evolutionary adaptation to blue light toxicity in Drosophila.Communications biology · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
The impact of commensal bacteria on the host arises from complex microbial-diet-host interactions. Mapping metabolic interactions in gut microbial communities is therefore key to understand how the microbiome influences the host. Here we use an interdisciplinary approach including isotope-resolved metabolomics to show that in Drosophila melanogaster, Acetobacter pomorum (Ap) and Lactobacillus plantarum (Lp) a syntrophic relationship is established to overcome detrimental host diets and identify Ap as the bacterium altering the host's feeding decisions. Specifically, we show that Ap uses the lactate produced by Lp to supply amino acids that are essential to Lp, allowing it to grow in imbalanced diets. Lactate is also necessary and sufficient for Ap to alter the fly's protein appetite. Our data show that gut bacterial communities use metabolic interactions to become resilient to detrimental host diets. These interactions also ensure the constant flow of metabolites used by the microbiome to alter reproduction and host behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.