Evidence map›Paper›PMID 32843565›Full record

ArticleDiabetes2020

Defining Heterogeneity Among Women With Gestational Diabetes Mellitus.

Camille E Powe, Marie-France Hivert, Miriam S Udler

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06542718 (Studying the Heterogeneity of Gestational Diabetes Mellitus), which is not on this map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06542718 recruitingnot on this mapstarted 2022, after this paper: background citation

Studying the Heterogeneity of Gestational Diabetes Mellitus: Cardio-Metabolic Alteration and Treatment Response in a Multi-Ethnic Population in Singapore (GDM-CARE)

TypeobservationalSponsorNational University Health System, SingaporeRan2022 to 2026Enrolled800ConditionsGestational Diabetes, Pregnancy Related, Pregnancy Complications, Birth Weight
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Observational
  8. Article
  9. Review
  10. Early Gestational Diabetes Mellitus: A Need for Better Understanding and Wise Navigation.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Observational
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Camille E PoweDiabetes Unit, Massachusetts General Hospital, Boston, MA camille.powe@mgh.harvard.edu.ORCID 0000-0002-7060-7778
Marie-France HivertDiabetes Unit, Massachusetts General Hospital, Boston, MA.ORCID 0000-0001-7752-2585
Miriam S UdlerDiabetes Unit, Massachusetts General Hospital, Boston, MA.ORCID 0000-0003-3824-9162
Broad Institute · USHarvard University · US

Funding

Elucidating Determinants of Gestational Beta-Cell Adaptation and FailureK23DK113218 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI POWE, CAMILLE ELISE · 2017 to 2021
$1.0M
Clinical Implications of Genetically Defined Diabetes Subtypes and Application to Electronic Health Medical Record SystemsK23DK114551 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI UDLER, MIRIAM SARGON · 2017 to 2021
$1000k
NIDDK NIH HHS K23 DK113218NIDDK NIH HHS K23 DK114551NIDDK NIH HHS L30 DK106874
6 · The paper itself

Abstract

Attention to precision medicine in type 2 diabetes (T2D) has provided two favored approaches to subclassifying affected individuals and parsing heterogeneity apparent in this condition: phenotype-based and genotype-based. Gestational diabetes mellitus (GDM) shares phenotypic characteristics with T2D. However, unlike T2D, GDM emerges in the setting of profound pregnancy-related physiologic changes in glucose metabolism. T2D and GDM also share common genetic architecture, but there are likely to be unique genetic influences on pregnancy glycemic regulation that contribute to GDM. In this Perspective, we describe efforts to decipher heterogeneity in T2D and detail how we and others are applying approaches developed for T2D to the study of heterogeneity in GDM. Emerging results reveal the potential of phenotype- and genotype-based subclassification of GDM to deliver the promise of precision medicine to the obstetric population.

Indexed as

AdultDiabetes, GestationalDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGenotypeGlucose Tolerance TestHumansInsulin ResistancePolymorphism, Single NucleotidePregnancy

Identifiers

PMID32843565
PMCPMC7506831
OpenAlexW3080873088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.