Evidence map›Paper›PMID 32843557›Full record

ArticlemBio2020

Cervicovaginal Microbiome Composition Is Associated with Metabolic Profiles in Healthy Pregnancy.

Andrew Oliver, Brandon LaMere, Claudia Weihe, Stephen Wandro, Karen L Lindsay, Pathik D Wadhwa, David A Mills, David T Pride, Oliver Fiehn, Trent Northen and 5 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05122065 (Defining the Vaginal Microbiome and the Vaginal pH of Menopausal Women With and Without Genitourinary Syndrome and With and Without Hormone Replacement Therapy), which is not on this map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05122065 unknown statusnot on this mapstarted 2021, after this paper: background citation

Defining the Vaginal Microbiome and the Vaginal pH of Menopausal Women With and Without Genitourinary Syndrome and With and Without Hormone Replacement Therapy

TypeobservationalSponsorFemTec Health Inc.Ran2021 to 2022Enrolled432ConditionsMenopause, Hormone Replacement Therapy, Genitourinary Syndrome of Menopause
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 56 citations in OpenAlex.

  1. Trial
  2. Trial
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  4. Article
  5. Article
  6. Vaginal microbiome and its implications in preterm birth.Obstetrics & gynecology science · 2025
    Review
  7. Article
  8. Review
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  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Andrew OliverDepartment of Molecular Biology and Biochemistry, University of California, Irvine.
Brandon LaMereDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco.
Claudia WeiheDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, California, USA.
Stephen WandroCenter for Microbiome Innovation, University of California, San Diego, San Diego, California, USA.
Karen L LindsayDepartment of Pediatrics and the Development, Health and Disease Research Program, College of Health Sciences, University of California, Irvine, Irvine, California, USA.
Pathik D WadhwaDepartment of Pediatrics and the Development, Health and Disease Research Program, College of Health Sciences, University of California, Irvine, Irvine, California, USA.
David A MillsDepartment of Food Science and Technology, University of California, Davis, Davis, California, USA.
David T PrideDepartment of Pathology, University of California, San Diego, San Diego, California, USA.
Oliver FiehnWest Coast Metabolomics Center, University of California, Davis, Davis, California, USA.
Trent NorthenEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Markus de RaadEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Huiying LiDepartment of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Jennifer B H MartinyDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, California, USA.
Susan LynchDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco.
Katrine WhitesonDepartment of Molecular Biology and Biochemistry, University of California, Irvine katrine@uci.edu.ORCID 0000-0002-5423-6014
University of California, Irvine · USLawrence Berkeley National Laboratory · USUniversity of California, Davis · USUniversity of California San Diego · USUniversity of California, San Francisco · USUniversity of California, Los Angeles · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
T32 for Training in Microbiology & Infectious DiseasesT32AI141346 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Celia Goulding, Melissa Bruckner Lodoen · 2019 to 2026
$1.0M
NCATS NIH HHS UL1 TR001414NIAID NIH HHS T32 AI141346
6 · The paper itself

Abstract

Microbes and their metabolic products influence early-life immune and microbiome development, yet remain understudied during pregnancy. Vaginal microbial communities are typically dominated by one or a few well-adapted microbes which are able to survive in a narrow pH range and are adapted to live on host-derived carbon sources, likely sourced from glycogen and mucin present in the vaginal environment. We characterized the cervicovaginal microbiomes of 16 healthy women throughout the three trimesters of pregnancy. Additionally, we analyzed saliva and urine metabolomes using gas chromatography-time of flight mass spectrometry (GC-TOF MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) lipidomics approaches for samples from mothers and their infants through the first year of life. Amplicon sequencing revealed most women had either a simple community with one highly abundant species of

Indexed as

MetabolomeMicrobiotaAdultCervix UteriChromatography, LiquidCohort StudiesFemaleHealthy VolunteersHumansInfantMetabolomicsPregnancyRNA, Ribosomal, 16STandem Mass SpectrometryVaginaYoung AdultRNA, Ribosomal, 16SLactobacilluslongitudinalmetabolomemicrobiomepregnancyvagina

Identifiers

PMID32843557
PMCPMC7448280
OpenAlexW3081281014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.