Evidence map›Paper›PMID 32843553›Full record

ArticlemBio2020

Mycobacterium tuberculosis Rv0991c Is a Redox-Regulated Molecular Chaperone.

Samuel H Becker, Kathrin Ulrich, Avantika Dhabaria, Beatrix Ueberheide, William Beavers, Eric P Skaar, Lakshminarayan M Iyer, L Aravind, Ursula Jakob, K Heran Darwin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Future Research Directions on Mycobacterium tuberculosis Proteins.Advances in experimental medicine and biology · 2026
    Review
  3. Article
  4. Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  5. Transcriptional Response ofFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Samuel H BeckerDepartment of Microbiology, New York University School of Medicine, New York, New York, USA samuelb51490@gmail.com heran.darwin@med.nyu.edu.
Kathrin UlrichDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Avantika DhabariaProteomics Laboratory, Division of Advanced Research Technologies, New York University School of Medicine, New York, New York, USA.
Beatrix UeberheideProteomics Laboratory, Division of Advanced Research Technologies, New York University School of Medicine, New York, New York, USA.
William BeaversVanderbilt Institute of Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Eric P SkaarVanderbilt Institute of Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Lakshminarayan M IyerNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
L AravindNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Ursula JakobDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-4020-4572
K Heran DarwinDepartment of Microbiology, New York University School of Medicine, New York, New York, USA samuelb51490@gmail.com heran.darwin@med.nyu.edu.ORCID 0000-0002-5043-7548
New York University · USNational Institutes of Health · USUniversity of Michigan · USVanderbilt University Medical Center · US

Funding

Evolutionary Analysis and Comparative Genomics of Protein SuperfamiliesZIALM594244 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ARAVIND, L · 2009 to 2025
$20.3M
INFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9M
Role of Molecular Chaperones in Stress Response and DiseaseR35GM122506 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ursula H. Jakob · 2017 to 2026
$6.8M
PROTEASOME-DEPENDENT DEGRADATION IN MYCOBACTERIUM TUBERCULOSISR01AI088075 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Katerina Heran Darwin · 2011 to 2026
$6.5M
Mechanism and function of heme-iron utilization in staphylococcal pathogenesisR01AI069233 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2006 to 2020
$5.6M
The Staphylococcus aureus response to nutrient zinc restriction during infectionR01AI150701 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2020 to 2024
$2.1M
Virulence Regulation by the Mycobacterium tuberculosis ProteasomeR56AI144851 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DARWIN, KATERINA HERAN · 2019 to 2019
$548k
NIAID NIH HHS R01 AI069233NIAID NIH HHS R01 AI088075NIAID NIH HHS R01 AI150701NIAID NIH HHS R56 AI144851NIAID NIH HHS T32 AI007180NIGMS NIH HHS R35 GM122506
6 · The paper itself

Abstract

The bacterial pathogen

Indexed as

Molecular ChaperonesAnimalsBacterial ProteinsEscherichia coli ProteinsFemaleHeat-Shock ProteinsHumansMiceMice, Inbred C57BLMycobacterium tuberculosisOxidation-ReductionOxidative StressProtein FoldingProtein StabilityBacterial ProteinsEscherichia coli ProteinsHeat-Shock ProteinsHSP33 protein, E coliMolecular ChaperoneschaperoneHsp70Mycobacteriumproteinproteostasistuberculosis

Identifiers

PMID32843553
PMCPMC7448276
OpenAlexW3081416624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.