Evidence map›Paper›PMID 32843528›Full record

ArticleDevelopment (Cambridge, England)2020

Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes.

Michael A Flinn, Cécile Otten, Zachary J Brandt, Jonathan R Bostrom, Aria Kenarsary, Tina C Wan, John A Auchampach, Salim Abdelilah-Seyfried, Caitlin C O'Meara, Brian A Link

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Michael A FlinnDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Cécile OttenInstitute for Biochemistry and Biology, University of Potsdam, 14476 Potsdam, Germany.
Zachary J BrandtDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Jonathan R BostromDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Aria KenarsaryDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Tina C WanCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
John A AuchampachCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Salim Abdelilah-SeyfriedInstitute for Biochemistry and Biology, University of Potsdam, 14476 Potsdam, Germany.
Caitlin C O'MearaCardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Brian A LinkDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA blink@mcw.edu.ORCID 0000-0002-7173-2642
Medical College of Wisconsin · USUniversity of Potsdam · DE

Funding

Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
IL13 - A Novel Therapeutic Factor for Cardiac RegenerationR01HL141159 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI O'MEARA, CAITLIN C · 2019 to 2023
$2.1M
Tip60, Ischemic Heart Disease and RegenerationR01HL131788 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A, LOUGH, JOHN W · 2017 to 2020
$2.0M
VisualSonics Vevo 3100 High-Frequency Ultrasound Imaging SystemS10OD025038 · OD · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2019 to 2019
$302k
NHLBI NIH HHS R01 HL131788NHLBI NIH HHS R01 HL141159NHLBI NIH HHS T32 HL134643NIH HHS S10 OD025038
6 · The paper itself

Abstract

The Hippo-Yap pathway regulates multiple cellular processes in response to mechanical and other stimuli. In

Indexed as

AnimalsCell Cycle ProteinsHeartMyocytes, CardiacProtein StabilityTrans-ActivatorsYAP-Signaling ProteinsZebrafishZebrafish ProteinsCell Cycle ProteinsLlgl1 protein, zebrafishTrans-ActivatorsYAP-Signaling ProteinsYes-associated protein (yap), zebrafishZebrafish ProteinsCardiac developmentHippo-Yap pathwayValvulogenesisZebrafish

Identifiers

PMID32843528
PMCPMC7473637
OpenAlexW3081109055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.