ArticleInfectious diseases of poverty2020
Epidemiology of tuberculosis in Sabah, Malaysia, 2012-2018.
Article in Infectious diseases of poverty, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Development of a clinical algorithm-based scoring system to diagnose smear-negative pulmonary tuberculosis in Sabah, Malaysia using the modified Delphi method.Journal of global health · 2026Article
- Treatment outcomes of drug-resistant tuberculosis in Sabah, Malaysia - a retrospective cohort study.Public health in practice (Oxford, England) · 2025Article
- miRNA Differential Expression Profile Analysis and Identification of Potential Key Genes in Active Tuberculosis.Journal of cellular and molecular medicine · 2025Article
- Article
- Exploring Barriers to Timely Diagnosis and Treatment of Tuberculosis in Selangor, Malaysia: A Qualitative Study.The American journal of tropical medicine and hygiene · 2024Article
- The incidence, and spatial trends of cholera in Sabah over 15 years: Repeated outbreaks in coastal areas.PLOS global public health · 2024Article
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- Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model.Tuberculosis and respiratory diseases · 2023Article
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- Treatment outcomes of extended versus nonextended intensive phase in pulmonary tuberculosis smear positive patients with delayed sputum smear conversion: A retrospective cohort study at primary care clinics in Kota Kinabalu.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2023Article
- Demography and clinical pattern of newly diagnosed uveitis patients in Malaysia.Journal of ophthalmic inflammation and infection · 2022Article
- Clinical characteristics and chest computed tomography findings related to the infectivity of pulmonary tuberculosis.BMC infectious diseases · 2021Article
- Tuberculosis Death Epidemiology and Its Associated Risk Factors in Sabah, Malaysia.International journal of environmental research and public health · 2021Article
- Case Report: Unusual High-Grade Diffuse Leptomeningeal Glioneuronal Tumor Mimicking Tuberculous Meningitis in a Child From an Endemic Region.Frontiers in pediatrics · 2021Article
- Diagnostic challenges and Gene-Xpert utility in detecting Mycobacterium tuberculosis among suspected cases of Pulmonary tuberculosis.PloS one · 2021Article
- The whole genome sequence data analyses of aData in brief · 2020Article
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7 authors.
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Abstract
backgroundTuberculosis (TB) is of high public health importance in Malaysia. Sabah State, located on the island of Borneo, has previously reported a particularly high burden of disease and faces unique contextual challenges compared with peninsular Malaysia. The aim of this study is to describe the epidemiology of TB in Sabah to identify risk groups and hotspots of TB transmission.
methodsWe conducted a retrospective review of TB cases notified in Sabah, Malaysia, between 2012 and 2018. Using data from the state's 'myTB' notification database, we calculated the case notification rate and described trends in the epidemiology, diagnostic practices and treatment outcomes of TB in Sabah within this period. The Chi-squared test was used for determining the difference between two proportions.
resultsBetween 2012 and 2018 there were 33 193 cases of TB reported in Sabah (128 cases per 100 000 population). We identified several geographic hotspots, including districts with > 200 cases per 100 000 population per year. TB rates increased with age and were highest in older males. Children < 15 years accounted for only 4.6% of cases. Moderate or advanced disease on chest X-ray and sputum smear positivity was high (58 and 81% of cases respectively), suggesting frequent late diagnosis. Multi-drug resistant (MDR) TB prevalence was low (0.3% of TB cases), however, rapid diagnostic test coverage was low (1.2%) and only 18% of all cases had a positive culture result. Treatment success was 83% (range: 81-85%) in those with drug-sensitive TB and 36% (range: 25-45%) in cases of MDR-TB.
conclusionBetween 2012 and 2018, TB notifications in Sabah State equated to 20% of Malaysia's total TB notifications, despite Sabah representing only 10% of Malaysia's population. We found hotspots of TB in urbanised population hubs and points of migration, as well as evidence of late presentation and diagnosis. Ensuring universal health coverage and expansion of GeneXpert® coverage is recommended to reduce barriers to care and early diagnosis and treatment for TB.
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