Evidence map›Paper›PMID 32843075›Full record

ArticleTrials2020

Protein delivery in intermittent and continuous enteral nutrition with a protein-rich formula in critically ill patients-a protocol for the prospective randomized controlled proof-of-concept Protein Bolus Nutrition (Pro BoNo) study.

Simona Reinhold, Desirée Yeginsoy, Alexa Hollinger, Atanas Todorov, Lionel Tintignac, Michael Sinnreich, Caroline Kiss, Caroline E Gebhard, Balázs Kovács, Bianca Gysi and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03587870 (Protein Delivery in Intermittent and Continuous Enteral Nutrition in ICU Patients A Prospective, Randomised Controlled Pilot Study in Critical Ill Patients With a Protein-rich Formula), which is not on this map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03587870 nacompletednot on this map

Protein Delivery in Intermittent and Continuous Enteral Nutrition in ICU Patients A Prospective, Randomised Controlled Pilot Study in Critical Ill Patients With a Protein-rich Formula

TypeinterventionalSponsorUniversity Hospital, Basel, SwitzerlandRan2019 to 2026Enrolled113ConditionsMuscle Wasting in Critically IllArmsEnteral nutrition with Fresubin Intensive
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Simona ReinholdIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
Desirée YeginsoyIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
Alexa HollingerIntensive Care Unit, University Hospital Basel, Basel, Switzerland. alexa.hollinger@usb.ch.ORCID http://orcid.org/0000-0001-6799-1652
Atanas TodorovIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
Lionel TintignacDepartment of Biomedicine, University Hospital Basel, Basel, Switzerland.
Michael SinnreichDepartments of Biomedicine and Neurology, Centre of Neuromuscular Diseases, University Hospital Basel, Basel, Switzerland.
Caroline KissDepartment of Clinical Nutrition, University Department of Geriatric Medicine Felix Platter, Basel, Switzerland.
Caroline E GebhardIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
Balázs KovácsDepartment of Radiology, Musculoskeletal Diagnostics, University Hospital Basel, Basel, Switzerland.
Bianca GysiIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
Lara ImwinkelriedIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
Martin SiegemundIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
University Hospital of Basel · CHFelix Platter-Hospital · CH

Funding

Goldschmidt & Jacobson Foundation NA
6 · The paper itself

Abstract

backgroundCritically ill patients rapidly develop muscle wasting resulting in sarcopenia, long-term disability and higher mortality. Bolus nutrition (30-60 min period), whilst having a similar incidence of aspiration as continuous feeding, seems to provide metabolic benefits through increased muscle protein synthesis due to higher leucine peaks. To date, clinical evidence on achievement of nutritional goals and influence of bolus nutrition on skeletal muscle metabolism in ICU patients is lacking. The aim of the Pro BoNo study (Protein Bolus Nutrition) is to compare intermittent and continuous enteral feeding with a specific high-protein formula. We hypothesise that target quantity of protein is reached earlier (within 36 h) by an intermittent feeding protocol with a favourable influence on muscle protein synthesis.

methodsPro BoNo is a prospective randomised controlled study aiming to compare the impact of intermittent and continuous enteral feeding on preventing muscle wasting in 60 critically ill patients recruited during the first 48 h after ICU admission. The primary outcome measure is the time until the daily protein target (≥ 1.5 g protein/kg bodyweight/24 h) is achieved. Secondary outcome measures include tolerance of enteral feeding and evolution of glucose, urea and IGF-1. Ultrasound and muscle biopsy of the quadriceps will be performed. DISCUSSION: The Basel Pro BoNo study aims to collect innovative data on the effect of intermittent enteral feeding of critically ill patients on muscle wasting.

trial registrationClinicalTrials.gov NCT03587870 . Registered on July 16, 2018. Swiss National Clinical Trials Portal SNCTP000003234. Last updated on July 24, 2019.

Indexed as

Critical IllnessFood, FormulatedDietary ProteinsEnteral NutritionHumansIntensive Care UnitsProspective StudiesRandomized Controlled Trials as TopicDietary ProteinsAdult intensive and critical careNutrition and dieteticsUltrasound

Identifiers

PMID32843075
PMCPMC7449093
OpenAlexW3081026821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.