ArticleJournal of neuroengineering and rehabilitation2020
Rectus femoris hyperreflexia contributes to Stiff-Knee gait after stroke.
Article in Journal of neuroengineering and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06113965 (Neural Operant Conditioning to Improve Walking After Stroke), which is not on this map. Cited by 28 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neural Operant Conditioning to Improve Walking After Stroke
Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Homosynaptic Depression of the Soleus Predicts Post-Stroke Gait Speed.Restorative neurology and neuroscience · 2026Article
- Relationship between lower limb muscle coordination and knee flexion angle during the swing phase of gait in post-stroke individuals.Journal of neuroengineering and rehabilitation · 2026Article
- Task-Based Mapping of Compensatory Strategies and Movement Kinematics After Stroke: A Systematic Scoping Review.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Article
- Unaffected Side Hip-Knee Cyclogram for Assessing Gait and Balance in Ambulatory Hemiplegic Stroke Patients.Yonsei medical journal · 2026Article
- A Longitudinal Study of Physical Function Factors Related to Lower Limb Circumduction During Gait in Acute Stroke Patients with Hemiparesis.Sensors (Basel, Switzerland) · 2025Article
- Identification of stiff-knee gait in stroke survivors.BMC biomedical engineering · 2025Article
- Correlation study between lower limb muscle function and hemodynamics in hemiplegic patients after stroke: a prospective controlled study.European journal of physical and rehabilitation medicine · 2025Article
- Mechanisms of Post-stroke Stiff-Knee Gait: A Narrative Review.American journal of physical medicine & rehabilitation · 2025Review
- Deficit in intersegmental torques drives post-stroke stiff-knee gait.medRxiv : the preprint server for health sciences · 2025Article
- Does Gait Assistance Modulate Reflex Excitability in Those with Spasticity? A Preliminary Study.IEEE ... International Conference on Rehabilitation Robotics : [proceedings] · 2025Article
- Post-stroke Stiff-Knee gait: are there different types or different severity levels?Journal of neuroengineering and rehabilitation · 2025Article
- Between-limb difference in peak knee flexion angle can identify persons post-stroke with Stiff-Knee gait.Clinical biomechanics (Bristol, Avon) · 2024Article
- Can We Target Close Therapeutic Goals in the Gait Re-Education Algorithm for Stroke Patients at the Beginning of the Rehabilitation Process?Sensors (Basel, Switzerland) · 2024Article
- Case report: Intrathecal baclofen therapy improved gait pattern in a stroke patient with spastic dystonia.Frontiers in neurology · 2024Article
- Comparative electromyography analysis of subphase gait disorder in chronic stroke survivors.PeerJ · 2024Article
- Anatomical landmarks for ultrasound-guided rectus femoris diagnostic nerve block in post-stroke spasticity.Australasian journal of ultrasound in medicine · 2023Article
- Hip and Knee Joint Kinematics Predict Quadriceps Hyperreflexia in People with Post-stroke Stiff-Knee Gait.Annals of biomedical engineering · 2023Article
- Self-modulation of rectus femoris reflex excitability in humans.Scientific reports · 2023Article
- Stiff Knee Gait Disorders as Neuromechanical Consequences of Spastic Hemiplegia in Chronic Stroke.Toxins · 2023Article
- Altered biomechanical strategies of the paretic hip and knee joints during a step-up task.Topics in stroke rehabilitation · 2023Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStiff-Knee gait (SKG) after stroke is often accompanied by decreased knee flexion angle during the swing phase. The decreased knee flexion has been hypothesized to originate from excessive quadriceps activation. However, it is unclear whether hyperreflexia plays a role in this activation. The goal of this study was to establish the relationship between quadriceps hyperreflexia and knee flexion angle during walking in post-stroke SKG.
methodsThe rectus femoris (RF) H-reflex was recorded in 10 participants with post-stroke SKG and 10 healthy controls during standing and walking at the pre-swing phase. In order to attribute the pathological neuromodulation to quadriceps muscle hyperreflexia and activation, healthy individuals voluntarily increased quadriceps activity using electromyographic (EMG) feedback during standing and pre-swing upon RF H-reflex elicitation.
resultsWe observed a negative correlation (R = - 0.92, p = 0.001) between knee flexion angle and RF H-reflex amplitude in post-stroke SKG. In contrast, H-reflex amplitude in healthy individuals in presence (R = 0.47, p = 0.23) or absence (R = - 0.17, p = 0.46) of increased RF muscle activity was not correlated with knee flexion angle. We observed a body position-dependent RF H-reflex modulation between standing and walking in healthy individuals with voluntarily increased RF activity (d = 2.86, p = 0.007), but such modulation was absent post-stroke (d = 0.73, p = 0.296).
conclusionsRF reflex modulation is impaired in post-stroke SKG. The strong correlation between RF hyperreflexia and knee flexion angle indicates a possible regulatory role of spinal reflex excitability in post-stroke SKG. Interventions targeting quadriceps hyperreflexia could help elucidate the causal role of hyperreflexia on knee joint function in post-stroke SKG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.