ArticleBMC pediatrics2020
A clinical prediction model for complicated appendicitis in children younger than five years of age.
Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Appendiceal Perforation as a Potential Indicator of Healthcare Disparities Between Thai and Non-Thai Populations: A Nationwide Study of Public Hospitals in Thailand.Journal of racial and ethnic health disparities · 2026Article
- A Simple Preoperative Scoring System for Risk Stratification of Complicated Appendicitis in Children.Children (Basel, Switzerland) · 2026Article
- Differentiating Uncomplicated From Complicated Acute Appendicitis in Paediatric Patients With C-Reactive Protein and Imaging Findings-A Retrospective Single Centre Study in 1149 Patients.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Diagnostic value of pediatric appendicitis score for complicated appendicitis in preschool children.BMC pediatrics · 2026Article
- CLR (CRP to Lymphocytes) Score for Differentiating Simple and Complicated Appendicitis in Pediatric Patients.Journal of clinical medicine · 2026Article
- Development and validation of a nomogram based on C-reactive protein, neutrophil count, and respiratory rate for predicting complicated appendicitis in children.Pediatric surgery international · 2025Article
- Neutrophil percentage-to-albumin ratio for preoperative risk stratification of complicated appendicitis in children: a retrospective study.BMC gastroenterology · 2025Article
- Role of immature granulocyte and blood biomarkers in predicting perforated acute appendicitis using machine learning model.World journal of clinical cases · 2025Article
- Complicated appendicitis and associated risk factors among children.BMC pediatrics · 2025Article
- Analysis of Incidence and Risk Factors of Complicated Acute Appendicitis in Children: Evidence From a Tertiary Pediatric Center.International journal of pediatrics · 2025Article
- An interpretable and transparent machine learning framework for appendicitis detection in pediatric patients.Scientific reports · 2024Article
- Risk factors for acute complicated appendicitis in children aged three years and younger.BMC pediatrics · 2024Article
- Nomogram prediction model for length of hospital stay following laparoscopic appendectomy in pediatric patients: a retrospective study.Frontiers in pediatrics · 2024Article
- Trends in Simple and Complex Appendicitis in Children and the Potential Correlation to Common Viral Pathogens-A Retrospective Cohort Study between 2010 and 2019 in The Netherlands.Children (Basel, Switzerland) · 2023Article
- Pediatric Appendicitis Score or Ultrasonography? In Search of a Better Diagnostic Tool in Indian Children with Lower Abdominal Pain.Indian journal of pediatrics · 2023Article
- Trends and Predictors of Pediatric Negative Appendectomy Rates: A Single-Centre Retrospective Study.Children (Basel, Switzerland) · 2023Article
- Single-incision laparoscopic appendectomy versus traditional three-hole laparoscopic appendectomy for acute appendicitis in children by senior pediatric surgeons: a multicenter study from China.Frontiers in pediatrics · 2023Article
- Glucose indices as inflammatory markers in children with acute surgical abdomen: a cross-sectional study.Annals of medicine · 2023Article
- Predictors of Complicated Appendicitis with Evolution to Appendicular Peritonitis in Pediatric Patients.Medicina (Kaunas, Lithuania) · 2022Article
- Predictors and management outcomes of perforated appendicitis in sub-Saharan African countries: A retrospective cohort study.Annals of medicine and surgery (2012) · 2022Article
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4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNo reliably specific method for complicated appendicitis has been identified in children younger than five years of age. This study aimed to analyze the independent factors for complicated appendicitis in children younger than five years of age, develop and validate a prediction model for the differentiation of simple and complicated appendicitis.
methodsA retrospective study of 382 children younger than five years of age with acute appendicitis from January 2007 to December 2016 was conducted with assessments of demographic data, clinical symptoms and signs, and pre-operative laboratory results. According to intraoperative findings and postoperative pathological results, acute appendicitis was divided into simple and complicated appendicitis. Univariate and multivariate analyses were used to screen out the independent factors of complicated appendicitis, and develop a prediction model for complicated appendicitis. Then 156 such patients from January 2017 to December 2019 were collected as validation sample to validate the prediction model. Test performance of the prediction model was compared with the ALVARADO score and Pediatric Appendicitis Score (PAS).
resultsOf the 382 patients, 244 (63.9%) had complicated appendicitis. Age, white blood cell count, and duration of symptoms were the independent factors for complicated appendicitis in children younger than five years of age. The final predication model for complicated appendicitis included factors above. In validation sample, the prediction model exhibited a high degree of discrimination (area under the curve [AUC]: 0.830; 95% confidence interval [CI]: 0.762-0.885) corresponding to a optimal cutoff value of 0.62, and outperformed the PAS (AUC: 0.735; 95% CI: 0.658-0.802), ALVARADO score (AUC: 0.733; 95% CI: 0.657-0.801).
conclusionAge, white blood cell count, and duration of symptoms could be used to predict complicated appendicitis in children younger than five years of age with acute appendicitis. The prediction model is a novel but promising method that aids in the differentiation of acute simple and complicated appendicitis.
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