ArticleBMC genomics2020
Genome compartmentalization predates species divergence in the plant pathogen genus Zymoseptoria.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Conserved protein folds underpin the diversification of secreted proteins in a fungal pathogen.BMC microbiology · 2026Article
- Interspecies hybridization as a route of accessory chromosome origin in fungal pathogens.mBio · 2026Article
- Recurrent Chromosome Destabilization Through Repeat-Mediated Rearrangements in a Fungal Pathogen.Genome biology and evolution · 2026Article
- Three-dimensional genome architecture connects chromatin structure and function in a major wheat pathogen.BMC biology · 2025Article
- Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen.Nature communications · 2025Article
- Polygenic strategies for host-specific and general virulence of Botrytis cinerea across diverse eudicot hosts.Genetics · 2025Article
- Diversification, loss, and virulence gains of the major effector AvrStb6 during continental spread of the wheat pathogen Zymoseptoria tritici.PLoS pathogens · 2025Article
- Evolution of sympatric host-specialized lineages of the fungal plant pathogen Zymoseptoria passerinii in natural ecosystems.The New phytologist · 2025Article
- An array of Zymoseptoria tritici effectors suppress plant immune responses.Molecular plant pathology · 2024Article
- Copy number variation introduced by a massive mobile element facilitates global thermal adaptation in a fungal wheat pathogen.Nature communications · 2024Article
- Recent reactivation of a pathogenicity-associated transposable element is associated with major chromosomal rearrangements in a fungal wheat pathogen.Nucleic acids research · 2024Article
- A pangenome-guided manually curated library of transposable elements for Zymoseptoria tritici.BMC research notes · 2023Article
- Predicting chromosomal compartments directly from the nucleotide sequence with DNA-DDA.Briefings in bioinformatics · 2023Article
- Genome-Wide Characterization of Effector Protein-Encoding Genes inJournal of fungi (Basel, Switzerland) · 2023Article
- A thousand-genome panel retraces the global spread and adaptation of a major fungal crop pathogen.Nature communications · 2023Article
- Recent transposable element bursts are associated with the proximity to genes in a fungal plant pathogen.PLoS pathogens · 2023Article
- Article
- Differential Regulation and Production of Secondary Metabolites among Isolates of the Fungal Wheat Pathogen Zymoseptoria tritici.Applied and environmental microbiology · 2022Article
- Histone H3K27 Methylation Perturbs Transcriptional Robustness and Underpins Dispensability of Highly Conserved Genes in Fungi.Molecular biology and evolution · 2022Article
- Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus.Nature communications · 2021Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAntagonistic co-evolution can drive rapid adaptation in pathogens and shape genome architecture. Comparative genome analyses of several fungal pathogens revealed highly variable genomes, for many species characterized by specific repeat-rich genome compartments with exceptionally high sequence variability. Dynamic genome structure may enable fast adaptation to host genetics. The wheat pathogen Zymoseptoria tritici with its highly variable genome, has emerged as a model organism to study genome evolution of plant pathogens. Here, we compared genomes of Z. tritici isolates and of sister species infecting wild grasses to address the evolution of genome composition and structure.
resultsUsing long-read technology, we sequenced and assembled genomes of Z. ardabiliae, Z. brevis, Z. pseudotritici and Z. passerinii, together with two isolates of Z. tritici. We report a high extent of genome collinearity among Zymoseptoria species and high conservation of genomic, transcriptomic and epigenomic signatures of compartmentalization. We identify high gene content variability both within and between species. In addition, such variability is mainly limited to the accessory chromosomes and accessory compartments. Despite strong host specificity and non-overlapping host-range between species, predicted effectors are mainly shared among Zymoseptoria species, yet exhibiting a high level of presence-absence polymorphism within Z. tritici. Using in planta transcriptomic data from Z. tritici, we suggest different roles for the shared orthologs and for the accessory genes during infection of their hosts.
conclusionDespite previous reports of high genomic plasticity in Z. tritici, we describe here a high level of conservation in genomic, epigenomic and transcriptomic composition and structure across the genus Zymoseptoria. The compartmentalized genome allows the maintenance of a functional core genome co-occurring with a highly variable accessory genome.
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