ArticleProceedings. Biological sciences2020
Pace and stability of embryonic development affect telomere dynamics: an experimental study in a precocial bird model.
Article in Proceedings. Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Pooled it
- Environmental and Genetic Determinants of Early-Life Telomere Length in Tree Swallows.Molecular ecology · 2026Article
- Assortative breeding experiment in a songbird suggests telomere length is determined during early life rather than at conception.Scientific reports · 2025Article
- No Evidence That Life History Strategies Shape Within-Body Mosaics of Ageing.Molecular ecology · 2025Article
- Embryonic methionine triggers post-natal developmental programming in Japanese quail.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- How important is hidden phenotypic plasticity arising from alternative but converging developmental trajectories, and what limits it?The Journal of experimental biology · 2024Article
- Sex and early-life conditions shape telomere dynamics in an ectotherm.The Journal of experimental biology · 2024Article
- Why and when should organisms elongate their telomeres? Elaborations on the 'excess resources elongation' and 'last resort elongation' hypotheses.Ecology and evolution · 2023Article
- Heat-induced maternal effects shape avian eggshell traits and embryo development and phenotype at high incubation temperatures.Ecology and evolution · 2023Article
- Prenatal thyroid hormones accelerate postnatal growth and telomere shortening in wild great tits.The Journal of experimental biology · 2023Article
- Lizards from warm and declining populations are born with extremely short telomeres.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Causes and consequences of variation in early-life telomere length in a bird metapopulation.Ecology and evolution · 2022Article
- Hot and dry conditions predict shorter nestling telomeres in an endangered songbird: Implications for population persistence.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Experimental demonstration of prenatal programming of mitochondrial aerobic metabolism lasting until adulthood.Proceedings. Biological sciences · 2022Article
- The tarnished silver spoon? Trade-off between prenatal growth and telomere length in wild boar.Journal of evolutionary biology · 2022Article
- Nature vs. Nurture: Disentangling the Influence of Inheritance, Incubation Temperature, and Post-Natal Care on Offspring Heart Rate and Metabolism in Zebra Finches.Frontiers in physiology · 2022Article
- Gut microbiome and telomere length in gull hatchlings.Biology letters · 2021Article
- New Perspectives on Avian Models for Studies of Basic Aging Processes.Biomedicines · 2021Review
- Contrasting associations between nestling telomere length and pre and postnatal helpers' presence in a cooperatively breeding bird.Oecologia · 2021Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal effects on telomere length are increasingly recognized as a potential contributor to the developmental origin of health and adult disease. While it is becoming clear that telomere length is influenced by prenatal conditions, the factors affecting telomere dynamics during embryogenesis remain poorly understood. We manipulated both the pace and stability of embryonic development through varying incubation temperature and its stability in Japanese quail. We investigated the impact on telomere dynamics from embryogenesis to adulthood, together with three potential drivers of telomere shortening, growth rate, oxidative damage and prenatal glucocorticoid levels. Telomere length was not affected by our prenatal manipulation for the first 75% of embryogenesis, but was reduced at hatching in groups experiencing faster (i.e. high temperature) or less stable embryonic development. These early life differences in telomere length persisted until adulthood. The effect of developmental instability on telomere length at hatching was potentially mediated by an increased secretion of glucocorticoid hormones during development. Both the pace and the stability of embryo development appear to be key factors determining telomere length and dynamics into adulthood, with fast and less stable development leading to shorter telomeres, with the potential for adverse associated outcomes in terms of reduced longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.