ArticleProceedings. Biological sciences2020
Negative mood affects the expression of negative but not positive emotions in mice.
Article in Proceedings. Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed.
- Are mice a bad model for successive negative contrast?Learning & behavior · 2026Review
- Enhancing Rodent Welfare, Cost Savings, and Efficiency: Implementation and Review of Data-Driven Improvements.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Review
- The effects of handling on mouse behavior: cupped hands versus familiar or novel huts or tunnels.PloS one · 2025Article
- The implementation of tunnel handling in a mouse breeding facility revealed strain-specific behavioural responses.Laboratory animals · 2024Article
- Using refined methods to pick up mice: A survey benchmarking prevalence & beliefs about tunnel and cup handling.PloS one · 2023Article
- Use of nonaversive handling and training procedures for laboratory mice and rats: Attitudes of American and Canadian laboratory animal professionals.Frontiers in veterinary science · 2022Article
- Effects of non-aversive versus tail-lift handling on breeding productivity in a C57BL/6J mouse colony.PloS one · 2022Article
- Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice.International journal of molecular sciences · 2021Article
- Using the Judgment Bias Task to Identify Behavioral Indicators of Affective State: Do Eye Wrinkles in Horses Reflect Mood?Frontiers in veterinary science · 2021Article
- Negative mood affects the expression of negative but not positive emotions in mice.Proceedings. Biological sciences · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Whether and to what extent animals experience emotions is crucial for understanding their decisions and behaviour, and underpins a range of scientific fields, including animal behaviour, neuroscience, evolutionary biology and animal welfare science. However, research has predominantly focused on alleviating negative emotions in animals, with the expression of positive emotions left largely unexplored. Therefore, little is known about positive emotions in animals and how their expression is mediated. We used tail handling to induce a negative mood in laboratory mice and found that while being more anxious and depressed increased their expression of a discrete negative emotion (disappointment), meaning that they were less resilient to negative events, their capacity to express a discrete positive emotion (elation) was unaffected relative to control mice. Therefore, we show not only that mice have discrete positive emotions, but that they do so regardless of their current mood state. Our findings are the first to suggest that the expression of discrete positive and negative emotions in animals is not equally affected by long-term mood state. Our results also demonstrate that repeated negative events can have a cumulative effect to reduce resilience in laboratory animals, which has significant implications for animal welfare.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.