Evidence map›Paper›PMID 32842850›Full record

ArticleVirulence2020

Surfactant phospholipids act as molecular switches for premature induction of quorum sensing-dependent virulence in

Zhizhou Kuang, Richard C Bennett, Jingjun Lin, Yonghua Hao, Luchang Zhu, Henry T Akinbi, Gee W Lau

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Comparative analysis of theFrontiers in microbiology · 2025
    Article
  7. Article
  8. Article
  9. Bile effects on theHeliyon · 2023
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zhizhou KuangDepartment of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, IL, USA.
Richard C BennettDepartment of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, IL, USA.
Jingjun LinDepartment of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, IL, USA.ORCID 0000-0003-2363-1502
Yonghua HaoDepartment of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, IL, USA.
Luchang ZhuDepartment of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, IL, USA.ORCID 0000-0002-4064-5781
Henry T AkinbiDivision of Pulmonary Medicine, Cincinnati Children Hospital , Cincinnati, OH, USA.
Gee W LauDepartment of Pathobiology, University of Illinois at Urbana-Champaign , Urbana, IL, USA.
University of Illinois Urbana-Champaign · USCincinnati Children's Hospital Medical Center · US

Funding

Role of PA4878 in biofilm antimicrobial resistanceR01AI080710 · NIAID · STATE UNIVERSITY OF NY,BINGHAMTON · PI LAU, GEE W, SAUER, KARIN · 2009 to 2020
$3.1M
Controlling bactermic pneumococcal pneumonia with synthetic dominant-negative competence peptidesR01HL142626 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LAU, GEE W, TALGAN, YIFTAH · 2019 to 2022
$2.0M
Mechanisms of Pseudomonas Resistance to Membrane Permeabilization by SP-AR01HL090699 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LAU, GEE W · 2009 to 2012
$1.6M
NHLBI NIH HHS R01 HL090699NHLBI NIH HHS R01 HL142626NIAID NIH HHS R01 AI080710
6 · The paper itself

Abstract

The virulence behaviors of many Gram-negative bacterial pathogens are governed by quorum-sensing (QS), a hierarchical system of gene regulation that relies on population density by producing and detecting extracellular signaling molecules. Although extensively studied under

Indexed as

Quorum SensingAnimalsBacterial ProteinsCohort StudiesFemaleGene Expression Regulation, BacterialMaleMicePhospholipidsPneumonia, BacterialPseudomonas aeruginosaPulmonary SurfactantsVirulenceVirulence FactorsBacterial ProteinsPhospholipidsPulmonary SurfactantsVirulence Factorsdipalmitoylphosphatidylcholineelastase BPseudomonas aeruginosaquorum sensingrhamnolipidssurfactant phospholipidsvirulence expression

Identifiers

PMID32842850
PMCPMC7549932
OpenAlexW3081297646

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.