Evidence map›Paper›PMID 32842818›Full record

ReviewThe Journal of international medical research2020

Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2.

Adewale Oluwaseun Fadaka, Nicole Remaliah Samantha Sibuyi, Olusola Bolaji Adewale, Olalekan Olanrewaju Bakare, Musa Oyebowale Akanbi, Ashwil Klein, Abram Madimabe Madiehe, Mervin Meyer

Abstract readReview
In one paragraph

Review in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adewale Oluwaseun FadakaDepartment of Science and Innovation/Mintek Nanotechnology Innovation Centre, Biolabels Node, Department of Biotechnology, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa.ORCID https://orcid.org/0000-0002-3952-2098
Nicole Remaliah Samantha SibuyiDepartment of Science and Innovation/Mintek Nanotechnology Innovation Centre, Biolabels Node, Department of Biotechnology, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa.ORCID https://orcid.org/0000-0001-7175-5388
Olusola Bolaji AdewaleDepartment of Biotechnology, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa.
Olalekan Olanrewaju BakareBiochemistry Programme, Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
Musa Oyebowale AkanbiDepartment of Biotechnology, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa.
Ashwil KleinDepartment of Biotechnology, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa.ORCID https://orcid.org/0000-0002-5606-886X
Abram Madimabe MadieheDepartment of Science and Innovation/Mintek Nanotechnology Innovation Centre, Biolabels Node, Department of Biotechnology, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa.
Mervin MeyerDepartment of Science and Innovation/Mintek Nanotechnology Innovation Centre, Biolabels Node, Department of Biotechnology, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of coronavirus disease 2019 (COVID-19) in December 2019 has resulted in over 20 million cases and 741,808 deaths globally, affecting more than 200 countries. COVID-19 was declared a pandemic on 11 March 2020 by the World Health Organization. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). There is limited information on COVID-19, and treatment has so far focused on supportive care and use of repurposed drugs. COVID-19 can be transmitted via person-to-person contact through droplet spread. Some of the recommended precautionary measures to reduce the rate of disease spread include social distancing, good hygiene practices, and avoidance of crowded areas. These measures are effective because the droplets are heavy and can only travel approximately 1 meter in the air, settling quickly on fixed surfaces. Promising strategies to combat SARS-CoV-2 include discovery of therapeutic targets/drugs and vaccines. In this review, we summarize the epidemiology, pathophysiology, and diagnosis of COVID-19. We also address the mechanisms of action of approved repurposed drugs for therapeutic management of the disease.

Indexed as

PandemicsAdenosine MonophosphateAge FactorsAlanineAntibodies, Monoclonal, HumanizedAntiviral AgentsBetacoronavirusChloroquineCommunicable Disease ControlCoronavirus InfectionsCOVID-19Drug RepositioningHumansIncidencePersonal Protective EquipmentPhysical DistancingAdenosine MonophosphateAlanineAntibodies, Monoclonal, HumanizedAntiviral AgentsChloroquineremdesivirtocilizumab2019-nCoVACE-2CoronavirusCOVID-19repurposed drugsSARS-CoV-2

Identifiers

PMID32842818
PMCPMC7453465

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.