Evidence map›Paper›PMID 32842710›Full record

ArticleInternational journal of molecular sciences2020

Molecular Basis and Clinical Application of Growth-Factor-Independent In Vitro Myeloid Colony Formation in Chronic Myelomonocytic Leukemia.

Klaus Geissler, Eva Jäger, Agnes Barna, Michael Gurbisz, Temeida Graf, Elmir Graf, Thomas Nösslinger, Michael Pfeilstöcker, Sigrid Machherndl-Spandl, Reinhard Stauder and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 2 countries.

Klaus GeisslerMedical School, Sigmund Freud University, 1020 Vienna, Austria.
Eva JägerDepartment of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Agnes BarnaBlood Transfusion Service, Blood Transfusion Service for Upper Austria, Austrian Red Cross, 4020 Linz, Austria.
Michael GurbiszDepartment of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Temeida GrafDepartment of Internal Medicine V with Hematology, Oncology and Palliative Medicine, Hospital Hietzing, 1130 Vienna, Austria.
Elmir GrafDepartment of Internal Medicine V with Hematology, Oncology and Palliative Medicine, Hospital Hietzing, 1130 Vienna, Austria.
Thomas NösslingerDepartment of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.
Michael PfeilstöckerDepartment of Internal Medicine III, Hanusch Hospital, 1140 Vienna, Austria.
Sigrid Machherndl-SpandlDepartment of Internal Medicine I with Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Barmherzige Schwestern-Elisabethinen, 4020 Linz, Austria.
Reinhard StauderInternal Medicine V with Hematology and Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-8993-9561
Armin ZebischDepartment of Internal Medicine, Division of Hematology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-4861-7021
Heinz SillDepartment of Internal Medicine, Division of Hematology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0003-0993-4371
Leopold ÖhlerDepartment of Internal Medicine/Oncology, St. Josef Hospital, 1130 Vienna, Austria.
Rajko KusecSchool of Medicine, University of Zagreb, University Hospital Dubrava, 10000 Zagreb, Croatia.
Gregor HörmannDepartment of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Peter ValentLudwig Boltzmann Institute for Hematology and Oncology (LBI HO), Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-0456-5095
Medical University of Vienna · ATHanusch Hospital · ATInnsbruck Medical University · ATKlinik Hietzing · ATMedical University of Graz · ATAustrian Red Cross · ATOrdensklinikum Linz Barmherzige Schwestern · ATSigmund Freud Privatuniversität Wien · ATUniversity of Zagreb · HR

Funding

Austrian Science Fund (FWF) F4704-B20Gesellschaft zur Erforschung der Biologie und Therapie von Tumorkrankheiten ABCMML-112015
6 · The paper itself

Abstract

We have originally reported that colony-forming units granulocyte/macrophage (CFU-GM) formation is an in vitro feature of chronic myelomonocytic leukemia (CMML) and a strong predictor for short survival. Elucidation of the molecular basis underlying this in vitro phenomenon could be helpful to define molecular features that predict inferior outcome in patients. We studied the correlation between the mutational landscape and spontaneous colony formation in 164 samples from 125 CMML patients. As compared to wildtype samples, spontaneous in vitro CFU-GM formation was significantly increased in samples containing mutations in

Indexed as

AdultAgedAged, 80 and overAnimalsCell Line, TumorEnhancer of Zeste Homolog 2 ProteinFemaleGene Expression Regulation, LeukemicGTP PhosphohydrolasesHumansIntercellular Signaling Peptides and ProteinsJanus Kinase 2Leukemia, Myelomonocytic, ChronicMaleMembrane ProteinsMiceCBL protein, humanEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanGTP PhosphohydrolasesIntercellular Signaling Peptides and ProteinsJAK2 protein, humanJanus Kinase 2Membrane ProteinsNRAS protein, humanProto-Oncogene Proteins c-cblras ProteinsAMLCFU-GMCMMLin vitro culturesNGSprognosis

Identifiers

PMID32842710
PMCPMC7504428
OpenAlexW3080764891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.