Evidence map›Paper›PMID 32842706›Full record

ArticleInternational journal of molecular sciences2020

Analysis of Early Cone Dysfunction in an In Vivo Model of Rod-Cone Dystrophy.

Mark M Hassall, Michelle E McClements, Alun R Barnard, Maria Í Patricio, Sher A Aslam, Robert E Maclaren

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mark M HassallNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0002-6180-7954
Michelle E McClementsNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0002-2941-4464
Alun R BarnardNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Maria Í PatricioNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Sher A AslamNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Robert E MaclarenNuffield Laboratory of Ophthalmology, Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
University of Oxford · GB

Funding

Rhodes Trust direct scholarshipRoyal College of Surgeons of Edinburgh unknown
6 · The paper itself

Abstract

Retinitis pigmentosa (RP) is a generic term for a group of genetic diseases characterized by loss of rod and cone photoreceptor cells. Although the genetic causes of RP frequently only affect the rod photoreceptor cells, cone photoreceptors become stressed in the absence of rods and undergo a secondary degeneration. Changes in the gene expression profile of cone photoreceptor cells are likely to occur prior to observable physiological changes. To this end, we sought to achieve greater understanding of the changes in cone photoreceptor cells early in the degeneration process of the

Indexed as

AnimalsCone-Rod DystrophiesDisease Models, AnimalElectroretinographyGene Expression RegulationGenetic TherapyGenetic VectorsGreen Fluorescent ProteinsHEK293 CellsHomeodomain ProteinsHumansMice, TransgenicOphthalmoscopyRetinal Cone Photoreceptor CellsRhodopsinRod Opsinscone rod homeobox proteinGreen Fluorescent ProteinsHomeodomain ProteinsRhodopsinRod Opsinsshort-wavelength opsinTrans-Activatorscone photoreceptorsgene therapyretinaretinitis pigmentosarod-cone dystrophy

Identifiers

PMID32842706
PMCPMC7503557
OpenAlexW3081446086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.