Evidence map›Paper›PMID 32842596›Full record

ArticleInternational journal of molecular sciences2020

Colonic Mucosal Microbiota and Association of Bacterial Taxa with the Expression of Host Antimicrobial Peptides in Pediatric Ulcerative Colitis.

Jonna Jalanka, Jing Cheng, Kaisa Hiippala, Jarmo Ritari, Jarkko Salojärvi, Tarja Ruuska, Marko Kalliomäki, Reetta Satokari

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Jonna JalankaHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, P.O. Box 21, FI-00014 Helsinki, Finland.ORCID 0000-0002-3847-8136
Jing ChengHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, P.O. Box 21, FI-00014 Helsinki, Finland.ORCID 0000-0001-8761-8927
Kaisa HiippalaHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, P.O. Box 21, FI-00014 Helsinki, Finland.
Jarmo RitariFinnish Red Cross Blood Service, 00310 Helsinki, Finland.
Jarkko SalojärviSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
Tarja RuuskaDepartment of Pediatrics, University of Tampere and Tampere University Hospital, P.O. Box 2000, 33521 Tampere, Finland.
Marko KalliomäkiDepartment of Pediatrics, University of Turku and Turku University Central Hospital, P.O. Box 52, 20521 Turku, Finland.ORCID 0000-0002-9438-7052
Reetta SatokariHuman Microbiome Research Program, Faculty of Medicine, University of Helsinki, P.O. Box 21, FI-00014 Helsinki, Finland.ORCID 0000-0002-4258-3414
University of Helsinki · FIFinnish Red Cross · FINanyang Technological University · SGTampere University Hospital · FIUniversity of Turku · FI

Funding

Academy of Finland 316338Academy of Finland 323156Helsingin Yliopisto A three-year grantLastentautien Tutkimussäätiö 160048Sigrid Juséliuksen Säätiö Senior Research FellowVarsinais-Suomen Sairaanhoitopiiri EVO 13004
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD), are chronic debilitating disorders of unknown etiology. Over 200 genetic risk loci are associated with IBD, highlighting a key role for immunological and epithelial barrier functions. Environmental factors account for the growing incidence of IBD, and microbiota are considered as an important contributor. Microbiota dysbiosis can lead to a loss of tolerogenic immune effects and initiate or exacerbate inflammation. We aimed to study colonic mucosal microbiota and the expression of selected host genes in pediatric UC. We used high-throughput 16S rDNA sequencing to profile microbiota in colonic biopsies of pediatric UC patients (

Indexed as

AdolescentBacteroidetesbeta-DefensinsCase-Control StudiesChildChild, PreschoolColitis, UlcerativeDNA, RibosomalEnterobacteriaceaeFinlandGastrointestinal MicrobiomeGene ExpressionHumansInflammatory Bowel DiseasesIntestinal MucosaLipocalin-2beta-DefensinsDEFB1 protein, humanDEFB4A protein, humanDNA, RibosomalLCN2 protein, humanLipocalin-2Pancreatitis-Associated ProteinsPore Forming Cytotoxic ProteinsREG3G protein, humangene expressionhost-microbe cross-talkinflammatory bowel diseasemicrobiotaulcerative colitis

Identifiers

PMID32842596
PMCPMC7504357
OpenAlexW3080479705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.