Evidence map›Paper›PMID 32842562›Full record

ReviewNanomaterials (Basel, Switzerland)2020

Biocompatibility of Biomaterials for Nanoencapsulation: Current Approaches.

Bwalya A Witika, Pedzisai A Makoni, Scott K Matafwali, Billy Chabalenge, Chiluba Mwila, Aubrey C Kalungia, Christian I Nkanga, Alain M Bapolisi, Roderick B Walker

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Analyzing Molecular Determinants of Nanodrugs' Cytotoxic Effects.International journal of molecular sciences · 2025
    Pooled it
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  17. Antibacterial Activity of CuO Nanoparticles, Ethanolic Extract ofInternational journal of nanomedicine · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bwalya A WitikaDivision of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0002-4034-9368
Pedzisai A MakoniDivision of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0002-8475-447X
Scott K MatafwaliDepartment of Basic Sciences, School of Medicine, Copperbelt University, Ndola 10101, Zambia.
Billy ChabalengeDepartment of Market Authorization, Zambia Medicines Regulatory Authority, Lusaka 10101, Zambia.
Chiluba MwilaDepartment of Pharmacy, School of Health Sciences, University of Zambia, Lusaka 10101, Zambia.ORCID 0000-0003-0160-1222
Aubrey C KalungiaDepartment of Pharmacy, School of Health Sciences, University of Zambia, Lusaka 10101, Zambia.
Christian I NkangaDepartment of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of the Congo.ORCID 0000-0001-7712-478X
Alain M BapolisiDepartment of Chemistry, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.
Roderick B WalkerDivision of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0003-2781-4154

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoencapsulation is an approach to circumvent shortcomings such as reduced bioavailability, undesirable side effects, frequent dosing and unpleasant organoleptic properties of conventional drug delivery systems. The process of nanoencapsulation involves the use of biomaterials such as surfactants and/or polymers, often in combination with charge inducers and/or ligands for targeting. The biomaterials selected for nanoencapsulation processes must be as biocompatible as possible. The type(s) of biomaterials used for different nanoencapsulation approaches are highlighted and their use and applicability with regard to haemo- and, histocompatibility, cytotoxicity, genotoxicity and carcinogenesis are discussed.

Indexed as

biocompatibilitycytotoxicitygenotoxicityhaemocompatibilityhistocompatibilityliposomesmicellesnanocrystalsnanoencapsulationnanospherespolymerssurfactants

Identifiers

PMID32842562
PMCPMC7557593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.