Evidence map›Paper›PMID 32842469›Full record

ArticleInternational journal of molecular sciences2020

Direct Comparison of Therapeutic Effects on Diabetic Polyneuropathy between Transplantation of Dental Pulp Stem Cells and Administration of Dental Pulp Stem Cell-Secreted Factors.

Saki Kanada, Eriko Makino, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Masaki Hata, Taisuke Yamauchi, Noritaka Sawada, Shun Kondo, Tomokazu Saiki and 5 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  13. Neural crest-like stem cells for tissue regeneration.Stem cells translational medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Saki KanadaDepartment of Orthodontics, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Eriko MakinoDepartment of Orthodontics, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Nobuhisa NakamuraDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Megumi MiyabeDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Mizuho ItoDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Masaki HataDepartment of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.ORCID 0000-0002-9003-6562
Taisuke YamauchiDepartment of Orthodontics, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Noritaka SawadaDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Shun KondoDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Tomokazu SaikiDepartment of Pharmacy, Aichi Gakuin University, Dental Hospital, Nagoya 464-8651, Japan.
Tomomi MinatoDepartment of Clinical Laboratory, Aichi Gakuin University, Dental Hospital, Nagoya 464-8651, Japan.
Ken MiyazawaDepartment of Orthodontics, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Shigemi GotoDepartment of Orthodontics, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Tatsuaki MatsubaraDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Keiko NaruseDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Aichi Gakuin University · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology 21592506
6 · The paper itself

Abstract

Stem cell transplantation is a potential novel therapy for diabetic polyneuropathy. Dental pulp stem cells (DPSCs) are attractive stem cell sources because DPSCs can be isolated from extracted teeth and cryopreserved while retaining viability. In this study, we directly compared the efficacy of the transplantation of DPSCs and the administration of the secreted factors from DPSCs (DPSC-SFs) on diabetic polyneuropathy. Eight weeks after streptozotocin injection, DPSCs (1.0 × 10

Indexed as

AnimalsBlood GlucoseBody WeightCulture Media, ConditionedDental PulpDiabetes Mellitus, ExperimentalDiabetic NeuropathiesHindlimbMaleMotor NeuronsMuscle, SkeletalNerve FibersNerve Growth FactorsNeural ConductionRats, Sprague-DawleySciatic NerveBlood GlucoseCulture Media, ConditionedNerve Growth Factorsdental pulp stem celldiabetic polyneuropathyregenerative medicinesecreted factortransplantation

Identifiers

PMID32842469
PMCPMC7503871
OpenAlexW3081012303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.