Evidence map›Paper›PMID 32841923›Full record

ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2020

Redondovirus DNA in human respiratory samples.

Pietro Giorgio Spezia, Lisa Macera, Paola Mazzetti, Michele Curcio, Chiara Biagini, Ilaria Sciandra, Ombretta Turriziani, Michele Lai, Guido Antonelli, Mauro Pistello and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
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  6. Article
  7. Review
  8. Correlation of Redondovirus andInternational journal of molecular sciences · 2023
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Viruses · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Pietro Giorgio SpeziaDepartment of Translational Research, University of Pisa, Italy.
Lisa MaceraDepartment of Translational Research, University of Pisa, Italy; Virology Division, Pisa University Hospital, Pisa, Italy.
Paola MazzettiVirology Division, Pisa University Hospital, Pisa, Italy.
Michele CurcioImmunohematology 2, Pisa University Hospital, Pisa, Italy.
Chiara BiaginiImmunohematology 2, Pisa University Hospital, Pisa, Italy.
Ilaria SciandraNational Institute of Gastrenterology "S. De Bellis" Research Hospital Castellana, Bari, Italy.
Ombretta TurrizianiSapienza University of Rome, Rome, Italy.
Michele LaiDepartment of Translational Research, University of Pisa, Italy.
Guido AntonelliSapienza University of Rome, Rome, Italy.
Mauro PistelloDepartment of Translational Research, University of Pisa, Italy; Virology Division, Pisa University Hospital, Pisa, Italy.
Fabrizio MaggiDepartment of Translational Research, University of Pisa, Italy; Virology Division, Pisa University Hospital, Pisa, Italy. Electronic address: fabrizio.maggi@unipi.it.
University of Pisa · ITSapienza University of Rome · ITGastroenterology Hospital "Saverio de Bellis" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRedondovirus (ReDoV) is a recently discovered circular, Rep-encoding single-stranded DNA (CRESS-DNA) virus in humans. Its pathogenesis and clinical associations are still completely unknown.

methodsThe presence of ReDoV DNA was investigated in biological specimens of 543 Italian subjects by in-house developed PCR assays.

resultsThe overall ReDoV prevalence was about 4% (23 of 543 samples). The virus was detected in 22 of 209 (11 %) respiratory samples. One stool sample was also ReDoV positive. Viral DNA was not found in blood samples from immunocompetent and immunosuppressed subjects and cerebrospinal fluids from patients with neurological diseases. Genomic nucleotide differences were detected among the ReDoV isolates by sequencing a 582-nucleotide fragment of the capsid gene of the viral genome.

conclusionsThe results demonstrate that ReDoV is mainly present in the respiratory tract of infected people. Further investigations are needed to reveal possible clinical implications of this new CRESS-DNA virus in humans.

Indexed as

AdultAgedCapsid ProteinsDNA, ViralDNA VirusesDNA Virus InfectionsFecesFemaleGenetic VariationGenome, ViralHumansItalyMaleMiddle AgedPhylogenyPrevalenceCapsid ProteinsDNA, ViralHuman redondovirusReal-time PCRReDoV DNARespiratory tractSequencing

Identifiers

PMID32841923
PMCPMC7428698
OpenAlexW3049158366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.