Evidence map›Paper›PMID 32841841›Full record

ArticleBlood cells, molecules & diseases2020

Age-dependent characterization of carotid and cerebral artery geometries in a transgenic mouse model of sickle cell anemia using ultrasound and microcomputed tomography.

Christian P Rivera, Li Li, Shuangyi Cai, Nui Pei, George E McAlear, Keval Bollavaram, Oluwasanmi V Ariyo, Victor O Omojola, Hannah Song, Andrea L Alfonso and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood cells, molecules & diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Cerebral arteries in mice with sickle cell disease are exposed to larger areas of low wall shear stress.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  3. Sickle cell mice exhibit elevated plasma bilirubin and altered intracranial cerebral blood velocities that are exacerbated by hypoxia-reoxygenation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Christian P RiveraWallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, GA, USA; Department of Mechanics and Engineering Science at Peking University, Beijing, China.
Li LiDepartment of Mechanics and Engineering Science at Peking University, Beijing, China.
Shuangyi CaiWallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Nui PeiDepartment of Mechanics and Engineering Science at Peking University, Beijing, China.
George E McAlearWallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Keval BollavaramWallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Oluwasanmi V AriyoWallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Victor O OmojolaWallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Hannah SongWallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Andrea L AlfonsoWallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Wenchang TanDepartment of Mechanics and Engineering Science at Peking University, Beijing, China.
Yunlong HuoDepartment of Mechanics and Engineering Science at Peking University, Beijing, China.
Manu O PlattWallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, GA, USA; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: manu.platt@bme.gatech.edu.
The Wallace H. Coulter Department of Biomedical Engineering · USGeorgia Institute of Technology · USPeking University · CN

Funding

Multiscale, mechanistic, and predictive models of stroke in sickle cell diseaseDP2OD007433 · OD · GEORGIA INSTITUTE OF TECHNOLOGY · PI PLATT, MANU O · 2010 to 2010
$2.3M
Proteolytic mechanisms of arterial remodeling and strokes in sickle cell diseaseR56HL136210 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI PLATT, MANU O · 2017 to 2017
$511k
NHLBI NIH HHS R56 HL136210NIH HHS DP2 OD007433
6 · The paper itself

Abstract

To define morphological changes in carotid and cerebral arteries in sickle cell transgenic mice (SS) as they age, a combination of ultrasound and microcomputed tomography of plastinated arteries was used to quantify arterial dimensions and changes in mice 4, 12, and 24 weeks of age. 12-week SS mice had significantly larger common carotid artery diameters than AS mice, which continued through to the extracranial and intracranial portions of the internal carotid artery (ICA). There were also side specific differences in diameters between the left and right vessels. Significant ICA tapering along its length occurred by 12- and 24-weeks in SS mice, decreasing by as much as 70%. Significant narrowing along the length was also measured in SS anterior cerebral arteries at 12- and 24-weeks, but not AS. Collectively, these findings indicate that sickle cell anemia induces arterial remodeling in 12- and 24-weeks old mice. Catalog of measurements are also provided for the common carotid, internal carotid, anterior cerebral, and middle cerebral arteries for AS and SS genotypes, as a reference for other investigators using mathematical and computational models of age-dependent arterial complications caused by sickle cell anemia.

Indexed as

AgingAnemia, Sickle CellAnimalsCarotid ArteriesCerebral ArteriesDisease Models, AnimalFemaleHumansMaleMice, TransgenicUltrasonographyX-Ray MicrotomographyArteriesImagingMorphologySickle cell anemiaUltrasound

Identifiers

PMID32841841
PMCPMC7487197
OpenAlexW3049236210

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.