ArticleJournal of the mechanical behavior of biomedical materials2020
A comprehensive testing protocol for macro-scale mechanical characterization of knee articular cartilage with documented experimental repeatability.
Article in Journal of the mechanical behavior of biomedical materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- The Double-Edged Sword: Anterior Cruciate Ligament Reconstructions on Adolescent Patients-Growth Plate Surgical Challenges and Future Considerations.Journal of clinical medicine · 2024Review
- Advances in Additive Manufactured Scaffolds Mimicking the Osteochondral Interface.Advanced nanobiomed research · 2024Article
- Biomechanics of the Human Osteochondral Unit: A Systematic Review.Materials (Basel, Switzerland) · 2024Review
- Mechanical Properties of Fresh, Frozen and Vitrified Articular Cartilage.Annals of biomedical engineering · 2023Article
- Tumor matrix stiffness provides fertile soil for cancer stem cells.Cancer cell international · 2023Review
- Mesenchymal stem cells loaded on 3D-printed gradient poly(ε-caprolactone)/methacrylated alginate composite scaffolds for cartilage tissue engineering.Regenerative biomaterials · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Articular cartilage mechanics has been extensively studied with various approaches and mechanical characterization strategies. However testing protocols can be highly varying and difficult to reproduce, particularly for specimen-specific analyses. Detailed knowledge of testing protocols is important for reliable use in concordant finite element analyses. This study presents a detailed, robust procedure for cartilage testing-with multiple regions and per sample repeatability data. Samples were taken from femur, tibia and patella of a human cadaver knee and tested in unconfined compression, confined compression and uniaxial tension. Each test was repeated three times. The testing protocols provide elastic and time dependent characterization data. Results, for example equilibrium modulus of 0.28 (0.0024) MPa for patella under unconfined compression indicate that variability is well controlled and that protocol(s) presented here can generate repeatable specimen-specific data. As per the authors' knowledge this is the first study to report in-depth uncertainty assessment of the experimental procedures for multi-region knee cartilage characterization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.