Evidence map›Paper›PMID 32841746›Full record

ArticleThe journal of allergy and clinical immunology. In practice2021

Understanding Food-Related Allergic Reactions Through a US National Patient Registry.

Jamie L Fierstein, Dannielle Brown, Ruchi Gupta, Lucy Bilaver

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04653324 (The FARE Patient Registry), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04653324 recruitingnot on this map

The FARE Patient Registry: A Registry for the Food Allergy Community

Typeobservational_patient_registrySponsorFood Allergy Research & EducationRan2017 to 2027Enrolled23,000ConditionsFood Hypersensitivity, Anaphylaxis, Eosinophilic Esophagitis, Food Sensitivity
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Incidence of food allergic reactions among adolescents engaged in food allergy management.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Trial
  3. A Global Survey of Mental Health Treatment Experiences Among Food Allergy Patients and Caregivers.The journal of allergy and clinical immunology. In practice · 2025
    Article
  4. Immuno-PCR in the Analysis of Food Contaminants.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Assessing daily food allergy self-management among adolescents using a 24-hour recall interview.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jamie L FiersteinCenter for Food Allergy & Asthma Research, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Dannielle BrownCenter for Food Allergy & Asthma Research, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Ruchi GuptaCenter for Food Allergy & Asthma Research, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill; Department of Academic General Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill. Electronic address: R-gupta@northwestern.edu.
Lucy BilaverCenter for Food Allergy & Asthma Research, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Northwestern University · US

Funding

Northwestern University Minority Health and Health Disparities Research Training (NU-MHRT)T37MD014248 · NIMHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SIMON, MELISSA A. · 2019 to 2023
$1.4M
NIMHD NIH HHS T37 MD014248
6 · The paper itself

Abstract

backgroundAlthough previous studies have focused on unintentional food-related allergic reactions, few have explored the motivation of intentional exposure to a known food allergen, independent of oral food challenges and/or oral immunotherapy. Still, data on the frequency and context of food-related allergic reactions remain sparse.

objectiveTo identify the frequency and context of food-related allergic reactions among children and adults.

methodsWe analyzed surveys from the Patient Registry established by Food Allergy Research and Education. Multivariable logistic regression evaluated characteristics associated with having frequent food-related allergic reactions as well as intentional food-related allergic reactions.

resultsOver one-third of 4075 (37.7%) respondents reported having more than 1 food-related allergic reaction per year, and 12.8% reported having 1 reaction per year. Of the 3054 respondents who completed the most recent reaction survey, 9.9% of food allergen exposures were classified as intentional, 82.1% as unintentional, and 4.8% as medically related. Among children with intentional exposures, the most common reason was that the child had never had a serious reaction (50.0%), and among adults, it was the decision to take the risk anyway (47.8%). Cross-contamination was the most commonly cited reason for unintentional exposure (children: 24.1%; adults: 32.2%).

conclusionAmong patients in a national food allergy registry, reports of food-related allergic reactions were common, and a non-negligible number of intentional reactions were reported. Our findings indicate the need for research on reactions in and out of the emergency department as well as intentional risk-taking behavior.

Indexed as

Food HypersensitivityAdultAllergensChildFoodHumansRegistriesSurveys and QuestionnairesAllergensFood allergic reactionsFood allergyIntentional exposureReaction frequencyReaction severityTreatmentUnintentional exposure

Identifiers

PMID32841746
PMCPMC7829042
OpenAlexW3080107583

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.