Evidence map›Paper›PMID 32841547›Full record

ArticleArthritis care & research2021

Performance of the New 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus in Children and Young Adults.

Najla Aljaberi, Kim Nguyen, Catherine Strahle, Angela Merritt, Arjun Mathur, Hermine I Brunner

Open access · greenAbstract readComparative Study
In one paragraph

Article in Arthritis care & research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Early-onset lupus nephritis.Clinical kidney journal · 2024
    Review
  7. Revisiting Childhood-Onset Systemic Lupus Erythematosus.Turkish archives of pediatrics · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Najla AljaberiCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0002-1390-7934
Kim NguyenVeterans Affairs Cincinnati and University of Cincinnati Medical Center, Cincinnati, Ohio.
Catherine StrahleUniversity of Cincinnati Medical Center, Cincinnati, Ohio.
Angela MerrittCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Arjun MathurCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Hermine I BrunnerCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0001-9478-2987
Cincinnati Children's Hospital Medical Center · USCincinnati VA Medical Center · USUniversity of Cincinnati · US

Funding

Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO)P30AR076316 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI BRUNNER, HERMINE I · 2019 to 2023
$3.4M
NIAMS NIH HHS P30 AR076316
6 · The paper itself

Abstract

objectiveTo compare the diagnostic usefulness of the 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) to that of the 1997 ACR classification criteria for SLE when applied to youths (age ≤21 years) with SLE.

methodsData were extracted from electronic health records of patients followed at a large academic pediatric hospital. The treating rheumatologist's diagnosis of SLE served as the standard criterion for identifying SLE patients (cases). Controls were patients with juvenile dermatomyositis (DM), juvenile scleroderma, or juvenile systemic sclerosis (SSc). The 2019 EULAR/ACR criteria and the 1997 ACR criteria were tested against the standard criterion.

resultsA total of 112 SLE patients ages 2-21 years and 105 controls ages 1-19 years (66% juvenile DM, 34% juvenile scleroderma or juvenile SSc) were available for analysis. The 2019 EULAR/ACR criteria had significantly higher sensitivity (85% versus 72%; P = 0.023) and similar specificity (83% versus 87%; P = 0.456) than the 1997 ACR criteria. The mean ± SD 2019 EULAR/ACR classification summary scores were significantly higher among non-White than White patients (22.41 ± 10.04 versus 17.59 ± 9.19; P < 0.01). The sensitivity of the 2019 EULAR/ACR criteria in non-White/White patients was 92%/80% (P = 0.08) versus 83%/64% (P < 0.02) for the 1997 ACR criteria. The sensitivity of the 2019 EULAR/ACR criteria was not affected by age or sex.

conclusionThe 2019 EULAR/ACR criteria efficiently classify youths with SLE, irrespective of age, sex, and race. Compared to the 1997 ACR criteria, the new criteria are significantly more sensitive and similarly specific in youths with SLE.

Indexed as

Health Status IndicatorsAdolescentAge FactorsCase-Control StudiesChildChild, PreschoolElectronic Health RecordsFemaleHumansLupus Erythematosus, SystemicMalePredictive Value of TestsRace FactorsReproducibility of ResultsSex FactorsYoung Adult

Identifiers

PMID32841547
PMCPMC12446872
OpenAlexW3080522321

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.