ArticleEuropean journal of pain (London, England)2020
The pathophysiological nature of sarcomeres in trigger points in patients with myofascial pain syndrome: A preliminary study.
Article in European journal of pain (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Combining Ozonated Autohemotherapy with Pharmacological Therapy for Comorbid Insomnia and Myofascial Pain Syndrome: A Prospective Randomized Controlled Study.Pain research & management · 2022Trial
- The perspective of manual therapy as a fascia-directed biomechanical intervention in myofascial pain syndrome.Frontiers in medicine · 2026Article
- The protective model of myofascial trigger points: a testable systems-level framework based on strain-repair mismatch.Frontiers in physiology · 2026Article
- Reframing myofascial pain syndrome: pathological disorder or adaptive protective response?Therapeutic advances in musculoskeletal disease · 2026Review
- Effectiveness of Pulsed Radiofrequency of the Greater Occipital Nerve in Cervical Myofascial Pain Syndrome: A Retrospective Observational Study.Pain research & management · 2026Observational
- IGF-1R promotes pain-like behavior in rats with myofascial pain syndrome via the PI3K/AKT pathway.Scientific reports · 2025Article
- Integrating Ultrasound-Guided Injections and Peripheral Magnetic Stimulation in Chronic Myofascial/Lumbar Pain.Life (Basel, Switzerland) · 2025Article
- Prevalence and location of myofascial trigger points in dogs with osteoarthritis.Frontiers in veterinary science · 2025Article
- Platelet-derived Growth Factor Receptor-α Induces Contraction Knots and Inflammatory Pain-like Behavior in a Rat Model of Myofascial Trigger Points.Anesthesiology · 2024Article
- Review
- Summaries of the Padua symposium on myofascial pain, fibromyalgia, and fascial pain disorders, June 2023,European journal of translational myology · 2023Article
- Location of Trigger Points in a Group of Police Working Dogs: A Preliminary Study.Animals : an open access journal from MDPI · 2023Article
- Myofascial Pain Syndrome: A Nociceptive Condition Comorbid with Neuropathic or Nociplastic Pain.Life (Basel, Switzerland) · 2023Article
- Ultrasound Imaging and Guidance for Cervical Myofascial Pain: A Narrative Review.International journal of environmental research and public health · 2023Review
- Sensory and emotional responses to deep pressure stimulation at myofascial trigger points: a pilot study.Frontiers in neuroscience · 2023Article
- Latent myofascial trigger points injection therapy for adult cough variant asthma: A randomized controlled trial.Frontiers in medicine · 2023Article
- Efficacy and Effectiveness of Extracorporeal Shockwave Therapy in Patients with Myofascial Pain or Fibromyalgia: A Scoping Review.Medicina (Kaunas, Lithuania) · 2022Article
- Dexmedetomidine inhibits abnormal muscle hypertrophy of myofascial trigger pointsFrontiers in pharmacology · 2022Article
- RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation.Frontiers in cell and developmental biology · 2022Article
- Re-Examining Myofascial Pain Syndrome: Toward Biomarker Development and Mechanism-Based Diagnostic Criteria.Current rheumatology reports · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMyofascial pain syndrome (MPS) has a high global prevalence and is associated with myofascial trigger points (MTrPs) in taut bands or nodules. Little is known about the aetiology. The current study assessed the pathophysiological characteristics of MTrPs in MPS patients.
methodsBiopsies of the trapezius muscle were collected from the MTrPs of MPS patients (MTrP group; n = 29) and from healthy controls (control group; n = 24), and their morphologies were analysed via haematoxylin-eosin (H&E) and Masson staining. A protein microarray was used to detect the receptor tyrosine kinase (RTK) family proteins. mRNA and long non-coding RNA (lncRNA) sequencing and analysis were conducted, and immunohistochemistry and Western blotting were used to examine the expression of EphB and Rho family proteins.
resultsAbnormally contracted sarcomeres showed enlarged, round fibres without inflammation or fibrosis. An lncRNA-mRNA network analysis revealed activation of muscle contraction signalling pathways in MTrP regions. Among RTK family proteins, 15 exhibited increased phosphorylation, and two exhibited decreased phosphorylation in the MTrP regions relative to control levels. In particular, EphB1/EphB2 phosphorylation was increased on the muscle cell membranes of abnormal sarcomeres. RhoA and Rac1, but not cell division control protein 42 (Cdc42), were activated in the abnormal sarcomeres.
conclusionsEphB1/EphB2 and RhoA/Rac1 might play roles in the aetiology of abnormally contracted sarcomeres in MTrPs without inflammatory cell infiltration and fibrotic adhesion. SIGNIFICANCE: Contracted sarcomeres were found in MTrP regions, which is consistent with the MTrP formation hypothesis. EphB1/EphB2 and RhoA/Rac1 might play roles in the sarcomere contractile sites of MTrPs, which may be promising therapeutic targets.
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Registered trials
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