ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Heterogeneity in Association Between Cognitive Function and Gait Speed Among Older Adults: An Integrative Data Analysis Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Gender and age influence the association between gait speed and mild cognitive impairment in community-dwelling Japanese older adults: from the Japan Prospective Studies Collaboration for Ageing and Dementia (JPSC-AD).Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2023Article
- Examining the intersection of cognitive and physical function measures: Results from the brain networks and mobility (B-NET) study.Frontiers in aging neuroscience · 2023Article
- Gradient and Acceleration of Decline in Physical and Cognitive Functions in Older Adults: A Disparity Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Associations of walking impairment with visual impairment, depression, and cognitive function in U.S. older adults: NHANES 2013-2014.BMC geriatrics · 2022Article
- Cognitive impairment and low physical function among older Mexican Americans: findings from a 20-year follow-upAnnals of epidemiology · 2022Article
- Aging-related Alzheimer's disease-like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus).American journal of primatology · 2021Review
- Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer's disease.GeroScience · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIncreasing evidence shows that cognition and gait speed are associated and are important measures of health among older adults. However, previous studies have used different methods to assess these 2 outcomes and lack sufficient sample size to examine heterogeneity among subgroups. This study examined how the relationship between global cognitive function and gait speed are influenced by age, gender, and race utilizing an integrated data analysis approach.
methodData on cognition (Montreal Cognitive Assessment [MoCA], Mini-Mental Status Examination [MMSE], and Modified Mini-Mental State Examination [3MSE]) and gait speed (range: 4-400 m) were acquired and harmonized from 25 research studies (n = 2802) of adults aged 50+ from the Wake Forest Older American Independence Center. Multilevel regression models examined the relationship between predicted values of global cognitive function (MoCA) and gait speed (4-m walk), including heterogeneity by age, race, and gender.
resultsGlobal cognitive function and gait speed exhibited a consistent positive relationship among whites with increasing age, while this was less consistent for African Americans. That is, there was a low correlation between global cognitive function and gait speed among African Americans aged 50-59, a positive correlation in their 60s and 70s, then a negative correlation thereafter.
conclusionGlobal cognition and gait speed exhibited a curvilinear U-shaped relationship among whites; however, the association becomes inverse in African Americans. More research is needed to understand this racial divergence and could aid in identifying interventions to maintain cognitive and gait abilities across subgroups.
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