Evidence map›Paper›PMID 32841266›Full record

ArticlePloS one2020

Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs.

Alyssa R Martin, Aida Sivro, Zoe R Packman, Eshan U Patel, Livia R Goes, Lyle R McKinnon, Jacquie Astemborski, Gregory D Kirk, Shruti H Mehta, Claudia Cicala and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Alyssa R MartinDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Aida SivroCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
Zoe R PackmanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Eshan U PatelDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Livia R GoesDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Lyle R McKinnonCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
Jacquie AstemborskiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
Gregory D KirkDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
Shruti H MehtaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.ORCID 0000-0002-2523-0959
Claudia CicalaDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
James ArthosDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
Andrew D ReddDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.ORCID 0000-0003-4651-1423
Thomas C QuinnDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
National Institutes of Health · USJohns Hopkins University · USCentre for the AIDS Programme of Research in South Africa · ZA

Funding

The AIDS Linked to the Intravenous Experience (ALIVE) StudyU01DA036297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Gregory D Kirk, Shruti H Mehta · 2014 to 2026
$28.9M
INCIDENCE OF HIV INFECTIONS IN A COHORT OF IV DRUG USERSR01DA012568 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MEHTA, SHRUTI H · 1999 to 2017
$15.5M
Johns Hopkins HIV Epidemiology and Prevention Sciences Training ProgramT32AI102623 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Shruti H Mehta · 2013 to 2026
$5.3M
INCIDENCE OF HIV INFECTION IN A COHORT OF IV DRUG USERSR56DA012568 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MEHTA, SHRUTI H · 2013 to 2013
$833k
Patient-Oriented Research and Mentorship in HIV and Non-Communicable DiseasesK24AI118591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2015 to 2019
$766k
NIAID NIH HHS K24 AI118591NIAID NIH HHS T32 AI102623NIDA NIH HHS R01 DA012568NIDA NIH HHS R56 DA012568NIDA NIH HHS U01 DA036297
6 · The paper itself

Abstract

introductionWe performed a cross-sectional study of HIV-uninfected men and women who inject drugs from the ALIVE cohort to examine if black men and women who inject drugs have higher levels of CD4+ T cells expressing the integrin heterodimer α4β7 compared to white men and women. MATERIALS AND

methodsFlow cytometry was used to examine expression of α4β7 and other markers associated with different functional CD4+ T cell subsets in both men and women who inject drugs.

resultsHigher levels of α4β7, CCR5, and CCR6 were observed on CD4+ T cells from black participants compared with white participants. In a multivariable model, α4β7 expression differed by race, but not sex, age, or other factors. DISCUSSION: Black men and women express higher percentages of α4β7 expressing CD4+ T cells, which may play a role in HIV disease.

Indexed as

AdultBaltimoreBlack or African AmericanCD4-Positive T-LymphocytesCohort StudiesCross-Sectional StudiesFemaleFlow CytometryHIV SeronegativityHumansIntegrinsMaleMiddle AgedSubstance Abuse, IntravenousWhite Peopleintegrin alpha4beta7Integrins

Identifiers

PMID32841266
PMCPMC7447027
OpenAlexW3081226729

What OpenQuestion holds

Textmetadata
LicenceCC0
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.