Evidence map›Paper›PMID 32840870›Full record

ReviewThe Australasian journal of dermatology2021

A review of actinic keratosis, skin field cancerisation and the efficacy of topical therapies.

Robert Sinclair, Christopher Baker, Lynda Spelman, Madeleine Supranowicz, Beth MacMahon

Abstract readReview
In one paragraph

Review in The Australasian journal of dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Clinical and Dermoscopic Diagnosis of Actinic Keratosis.Dermatology practical & conceptual · 2024
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Method of Assessing Skin Cancerization and KeratosesClinical and experimental dermatology · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robert SinclairSpecialist Connect Services, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0002-7327-6855
Christopher BakerSt Vincent's Hospital, Melbourne, Victoria, Australia.
Lynda SpelmanSpecialist Connect Services, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0002-7330-4713
Madeleine SupranowiczSpecialist Connect Services, Brisbane, Queensland, Australia.
Beth MacMahonSpecialist Connect Services, Brisbane, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While a wide range of treatments exist for actinic keratosis and skin field cancerisation, the long-term benefits of the most common topical therapies are poorly defined. This report reviews the efficacy of the most commonly used topical therapies to treat regional or field lesions. Limited clinical and histopathological data are available on clearance rates at 12 months post-treatment for the most commonly used agents, with varied outcome measures making any comparison difficult. In general, total field clearance rates at 12 months are suboptimal for the most commonly employed agents. Given the increasing incidence of actinic keratosis and skin field cancerisation due to an ageing population, further research into the efficacy of therapies is critical to guide treatment choice.

Indexed as

Antineoplastic AgentsDiclofenacDisease ProgressionDiterpenesFluorouracilHumansImiquimodKeratosis, ActinicPhotochemotherapyRecurrenceSkin Neoplasms3-ingenyl angelateAntineoplastic AgentsDiclofenacDiterpenesFluorouracilImiquimodactinic keratosisnon-melanoma skin cancerskin field cancerisationskin neoplasmstopical therapy

Identifiers

PMID32840870
PMCPMC8247342

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.