Evidence map›Paper›PMID 32840469›Full record

SynthesisRadiology2020

T2 Relaxation Times at Cardiac MRI in Healthy Adults: A Systematic Review and Meta-Analysis.

Christopher A Hanson, Akshay Kamath, Matthew Gottbrecht, Sami Ibrahim, Michael Salerno

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Age-, sex-, and segment-specific myocardial T1 and T2 reference values in a healthy cohort: a prospective single-center study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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  9. Review
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  17. Cardiac MRI TRadiology advances · 2024
    Article
  18. Article
  19. Article
  20. Cardiac Magnetic Resonance Imaging in Heart Failure.Cardiovascular innovations and applications · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Christopher A HansonFrom the Department of Medicine, Cardiovascular Division (C.A.H., M.S.), Department of Medicine (A.K., S.I.), and Department of Radiology (M.S.), University of Virginia Health System, 1215 Lee St, Box 800158, Charlottesville, VA 22908; Department of Medicine, Cardiovascular Division, University of Massachusetts, Worcester, Mass (M.G.); and Department of Biomedical Engineering, University of Virginia, Charlottesville, Va (M.S.).ORCID 0000-0002-8002-6213
Akshay KamathFrom the Department of Medicine, Cardiovascular Division (C.A.H., M.S.), Department of Medicine (A.K., S.I.), and Department of Radiology (M.S.), University of Virginia Health System, 1215 Lee St, Box 800158, Charlottesville, VA 22908; Department of Medicine, Cardiovascular Division, University of Massachusetts, Worcester, Mass (M.G.); and Department of Biomedical Engineering, University of Virginia, Charlottesville, Va (M.S.).ORCID 0000-0002-2178-9149
Matthew GottbrechtFrom the Department of Medicine, Cardiovascular Division (C.A.H., M.S.), Department of Medicine (A.K., S.I.), and Department of Radiology (M.S.), University of Virginia Health System, 1215 Lee St, Box 800158, Charlottesville, VA 22908; Department of Medicine, Cardiovascular Division, University of Massachusetts, Worcester, Mass (M.G.); and Department of Biomedical Engineering, University of Virginia, Charlottesville, Va (M.S.).ORCID 0000-0001-5245-9356
Sami IbrahimFrom the Department of Medicine, Cardiovascular Division (C.A.H., M.S.), Department of Medicine (A.K., S.I.), and Department of Radiology (M.S.), University of Virginia Health System, 1215 Lee St, Box 800158, Charlottesville, VA 22908; Department of Medicine, Cardiovascular Division, University of Massachusetts, Worcester, Mass (M.G.); and Department of Biomedical Engineering, University of Virginia, Charlottesville, Va (M.S.).
Michael SalernoFrom the Department of Medicine, Cardiovascular Division (C.A.H., M.S.), Department of Medicine (A.K., S.I.), and Department of Radiology (M.S.), University of Virginia Health System, 1215 Lee St, Box 800158, Charlottesville, VA 22908; Department of Medicine, Cardiovascular Division, University of Massachusetts, Worcester, Mass (M.G.); and Department of Biomedical Engineering, University of Virginia, Charlottesville, Va (M.S.).ORCID 0000-0001-7051-1031
University of Virginia Health System · USUniversity of Massachusetts Chan Medical School · US

Funding

Training in Cardiovascular Imaging ResearchT32EB003841 · NIBIB · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jonathan R Lindner · 2004 to 2026
$4.4M
High-Resolution Whole Heart Quantitative CMR Perfusion Imaging in Ischemic Heart DiseaseR01HL131919 · NHLBI · UNIVERSITY OF VIRGINIA · PI ENNIS, DANIEL B · 2017 to 2021
$3.5M
NHLBI NIH HHS R01 HL131919NIBIB NIH HHS T32 EB003841
6 · The paper itself

Abstract

Background T2 mapping is an important cardiac MRI technique with applications in various conditions. However, a comprehensive evaluation of the T2 literature for normal values is lacking. Purpose To characterize the ranges of normal values and variability of myocardial T2 relaxation times using a systematic review and meta-analysis of the T2 literature. Materials and Methods PubMed and Cochrane Central were searched from June 2019 to January 2020 for myocardial T2 measurements in healthy adults. Studies quantifying T2 relaxation times conducted at 1.5 T or 3.0 T using gradient and spin-echo (GRASE) or T2-prepared balanced steady-state free precession sequences were included. Summary means were generated using a random-effects model. Subgroup analysis and meta-regression were performed to assess factors causing heterogeneity. Results Of the 2481 articles retrieved, 42 studies were included with 954 healthy adults (mean age, 42.4 years ± 10.5 [standard deviation]; 538 men). The pooled mean of T2 across studies was 52 msec at 1.5 T (95% confidence interval [CI]: 51 msec, 53 msec) and 46 msec at 3.0 T (95% CI: 44 msec, 48 msec) (

Indexed as

Healthy VolunteersHeartHumansImage EnhancementMagnetic Resonance ImagingReference Values

Identifiers

PMID32840469
PMCPMC7605362
OpenAlexW3080343390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.