Evidence map›Paper›PMID 32840230›Full record

ArticleInternational journal of stem cells2020

Intramyocardial Transplantation of Umbilical Cord Mesenchymal Stromal Cells in Chronic Ischemic Cardiomyopathy: A Controlled, Randomized Clinical Trial (HUC-HEART Trial).

A Tulga Ulus, Ceren Mungan, Murat Kurtoglu, Ferda Topal Celikkan, Mesut Akyol, Merve Sucu, Mustafa Toru, Serdar Savas Gul, Ozgur Cinar, Alp Can

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02323477 (The Efficacy and Safety Assessment of Human Umbilical Cord Stroma-derived Multipotent Stromal Cells in Myocardial Infarction; a Phase 1/2 Clinical Trial), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02323477 phase1 / phase2terminatednot on this map

The Efficacy and Safety Assessment of Human Umbilical Cord Stroma-derived Multipotent Stromal Cells in Myocardial Infarction; a Phase 1/2 Clinical Trial (HUC-HEART Study)

TypeinterventionalSponsorAnkara UniversityRan2015 to 2018Enrolled46ConditionsChronic Ischemic Cardiomyopathy, Coronary Artery Bypass SurgeryArmsstem cell transplantation
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

A Tulga UlusDepartment of Cardiovascular Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Ceren MunganAnkara University Biotechnology Institute and Sisbiyotek, Ankara, Turkey.
Murat KurtogluCardiovascular Surgery Division, Ankara Guven Hospital, Ankara, Turkey.
Ferda Topal CelikkanDepartment of Histology and Embryology, Laboratory for Stem Cells and Reproductive Cell Biology, Ankara University School of Medicine, Ankara, Turkey.
Mesut AkyolDepartment of Biostatistics, Ankara Yildirim Beyazit University, Ankara, Turkey.
Merve SucuAnkara University Biotechnology Institute and Sisbiyotek, Ankara, Turkey.
Mustafa ToruRadiology Division, Ankara Liv Hospital, Ankara, Turkey.
Serdar Savas GulVisart Medical Imaging Center, Ankara, Turkey.
Ozgur CinarDepartment of Histology and Embryology, Laboratory for Stem Cells and Reproductive Cell Biology, Ankara University School of Medicine, Ankara, Turkey.
Alp CanDepartment of Histology and Embryology, Laboratory for Stem Cells and Reproductive Cell Biology, Ankara University School of Medicine, Ankara, Turkey.
Ankara University · TRAnkara Yıldırım Beyazıt University · TRGüven Hospital · TRHacettepe University · TRLiv Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe HUC-HEART Trial (ClinicalTrials.gov Identifier: NCT02323477) was a controlled, prospective, phase I/II, multicenter, single-blind, three-arm randomized study of intramyocardial delivery of human umbilical cord-derived mesenchymal stromal cells (HUC-MSCs) combined with coronary artery bypass-grafting (CABG) in patients with chronic ischemic cardiomyopathy (CIC). The trial aimed to assess (i) the safety and the efficacy of cell transplantation during one-year follow-up, (ii) to compare the efficacy of HUC-MSCs with autologous bone-marrow- derived mononuclear cells (BM-MNCs) in the same clinical settings. METHODS AND

resultsFifty-four patients who were randomized to receive HUC-MSCs (23×10

conclusionsSignificant findings directly related to the intramyocardial delivery of HUC-MSCs justified their efficacy in CIC. Stricter patient selection criteria with precisely aligned cell dose and delivery intervals, rigorous follow-up by detailed diagnostic approaches would further help to clarify the responsiveness to the therapy.

Indexed as

Bone marrow MSCClinical trialIschemic cardiomyopathyStem cell therapyUmbilical cord MSC

Identifiers

PMID32840230
PMCPMC7691850
OpenAlexW3081223335

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.