Evidence map›Paper›PMID 32840201›Full record

Trial reportThe American journal of tropical medicine and hygiene2020

Impact of Low-Cost Point-of-Use Water Treatment Technologies on Enteric Infections and Growth among Children in Limpopo, South Africa.

Courtney L Hill, Kelly McCain, Mzwakhe E Nyathi, Joshua N Edokpayi, David M Kahler, Darwin J Operario, David D J Taylor, Natasha C Wright, James A Smith, Richard L Guerrant and 4 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Courtney L Hill1Department of Engineering Systems and Environment, University of Virginia, Charlottesville, Virginia.
Kelly McCain1Department of Engineering Systems and Environment, University of Virginia, Charlottesville, Virginia.
Mzwakhe E Nyathi3Department of Animal Science, University of Venda, Thohoyandou, South Africa.
Joshua N Edokpayi4Department of Hydrology and Water Resources Mining and Environmental Geology, University of Venda, Thohoyandou, South Africa.
David M Kahler5Center for Environmental Research and Education, Duquesne University, Pittsburgh, Pennsylvania.
Darwin J Operario6Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia.
David D J Taylor7Department of Civil and Mineral Engineering, University of Toronto, Toronto, Canada.
Natasha C Wright8Department of Mechanical Engineering, University of Minnesota Twin Cities, Minneapolis, Minnesota.
James A Smith1Department of Engineering Systems and Environment, University of Virginia, Charlottesville, Virginia.
Richard L Guerrant6Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia.
Amidou Samie9Department of Microbiology, University of Venda, Thohoyandou, South Africa.
Rebecca A Dillingham6Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia.
Pascal O Bessong9Department of Microbiology, University of Venda, Thohoyandou, South Africa.
Elizabeth T Rogawski McQuade6Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia.
University of Virginia · USUniversity of Venda · ZADuquesne University · USEngineering Systems (United States) · USUniversity of Minnesota · USUniversity of Toronto · CA

Funding

The Water and Health in Limpopo Innovations Fellowship ProgramD43TW009359 · FIC · UNIVERSITY OF VIRGINIA · PI GUERRANT, RICHARD L · 2012 to 2016
$1.7M
UVa MHIRT: Training Future Leaders to Address Global Rural Health DisparitiesT37MD008659 · NIMHD · UNIVERSITY OF VIRGINIA · PI DILLINGHAM, REBECCA A., KOOLS, SUSAN MCEVILLY · 2014 to 2018
$1.3M
Translation of epidemiologic findings in enteric disease to public health actionK01AI130326 · NIAID · UNIVERSITY OF VIRGINIA · PI ROGAWSKI MCQUADE, ELIZABETH TACKET · 2018 to 2022
$612k
FIC NIH HHS D43 TW009359NIAID NIH HHS K01 AI130326NIMHD NIH HHS T37 MD008659
6 · The paper itself

Abstract

Enteric infections early in life have been associated with poor linear growth among children in low-resource settings. Point-of-use water treatment technologies provide effective and low-cost solutions to reduce exposure to enteropathogens from drinking water, but it is unknown whether the use of these technologies translates to improvements in child growth. We conducted a community-based randomized controlled trial of two water treatment technologies to estimate their effects on child growth in Limpopo, South Africa. We randomized 404 households with a child younger than 3 years to receive a silver-impregnated ceramic water filter, a silver-impregnated ceramic tablet, a safe-storage water container alone, or no intervention, and these households were followed up quarterly for 2 years. We estimated the effects of the interventions on linear and ponderal growth, enteric infections assessed by quantitative molecular diagnostics, and diarrhea prevalence. The silver-impregnated ceramic water filters and tablets consistently achieved approximately 1.2 and 3 log reductions, respectively, in total coliform bacteria in drinking water samples. However, the filters and tablets were not associated with differences in height (height-for-age

Indexed as

Child DevelopmentChild HealthChild, PreschoolDiarrheaDiarrhea, InfantileDrinking WaterFamily CharacteristicsFiltrationHumansHygieneInfantInfant, NewbornInfection ControlIntestinal DiseasesSouth AfricaWaterborne DiseasesDrinking Water

Identifiers

PMID32840201
PMCPMC7543807
OpenAlexW3080805381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.