ArticlePublic health nutrition2021
BMI, high-sensitivity C-reactive protein and the conversion from metabolically healthy to unhealthy phenotype in Chinese adults: a cohort study.
Article in Public health nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Identification of age-specific risk factors for hyperuricemia: a machine learning-driven stratified analysis in health examination cohorts.BMC medical informatics and decision making · 2025Article
- Assessment of the Risk of Insulin Resistance in Workers Classified as Metabolically Healthy Obese.Nutrients · 2025Article
- The effects of weight loss and improved metabolic health status on the risk of non-alcoholic fatty liver disease-results from a prospective cohort in China.Frontiers in nutrition · 2023Article
- Evaluation of the predictive value of different dietary antioxidant capacity assessment methods on healthy and unhealthy phenotype in overweight and obese women.Journal of diabetes and metabolic disorders · 2022Article
- Association between non-alcoholic fatty liver disease and metabolically healthy deterioration across different body shape phenotypes at baseline and change patterns.Scientific reports · 2022Article
- Serum Folate Related to Five Measurements of Obesity and High-Sensitivity C-Reactive Protein in Korean Adults.Nutrients · 2022Article
- The long-term impact of elevated C-reactive protein levels during pregnancy on brain morphology in late childhood.Brain, behavior, and immunity · 2022Article
- Metabolically healthy obesity: Inflammatory biomarkers and adipokines in elderly population.PloS one · 2022Article
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Authors and funding
6 authors.
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Abstract
objectiveWe performed the cohort study to evaluate the association between BMI, high-sensitivity C-reactive protein (hs-CRP) and the conversion from metabolically healthy to unhealthy phenotype in Chinese adults.
designMetabolically healthy was defined as participants without history of metabolic diseases and with normal fasting blood glucose level, glycated Hb A1c level, blood pressure, lipid profile, serum uric acid level and liver ultrasonographic findings at baseline. Participants were either classified into normal weight (18·5 ≤ BMI < 24·0 kg/m2) and overweight (BMI ≥ 24·0 kg/m2) based on baseline BMI, or low (<1 mg/l) and high (≥1 mg/l) groups based on baseline hs-CRP. The conversion from metabolically healthy to unhealthy phenotype was deemed if any of the metabolic abnormalities had been confirmed twice or more during 5 years of follow-up.
resultsIncluded were 4855 (1942 men and 2913 women, aged 36·0 ± 8·9 years) metabolically healthy Chinese adults. We identified 1692 participants who converted to metabolically unhealthy phenotype during the follow-up. Compared with their counterparts, the adjusted hazards ratio of the conversion was 1·19 (95 % CI 1·07, 1·33) for participants with overweight, while it was 1·15 (95 % CI 1·03, 1·29) for those with high hs-CRP level (≥1 mg/l). Further adjustment of hs-CRP did not materially change the association between BMI and the conversion. However, the association between hs-CRP and the conversion was not significant after further adjustment of BMI. The sensitivity analysis generated similar results to main analysis.
conclusionBMI was associated with the risk of the conversion from metabolically healthy to unhealthy status in Chinese adults.
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