ArticleThe Journal of international medical research2020
Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia.
Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Ginger-Derived Extracellular Vesicles: A Natural Solution for Alopecia.Current drug delivery · 2026Article
- Association of Clinical Factors, IL4, and IL17 Levels with the Development of Postherpetic Neuralgia: A Prospective Study Among Patients with Herpes Zoster from India.Indian dermatology online journal · 2025Article
- Serum Inflammatory Cytokine Levels in Herpes Zoster Patients and Their Association with Postherpetic Neuralgia: A Prospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients.
methodsAffected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients.
resultsHE staining showed that the epidermis of PHN skin was thicker than that of contralateral normal skin. Compared with normal skin, there was more infiltration of inflammatory cells into the dermis of PHN skin. The cytokine array detected the presence of 21/40 cytokines; however, only interleukin (IL)-1α showed differential expression between PHN skin and normal skin. ELISA results for IL-1α, IL-16, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 were consistent with those of cytokine arrays.
conclusionsExpression of inflammatory cytokines in PHN skin was not significantly altered compared with normal skin. Chronic refractory pain in PHN is not necessarily associated with increased inflammation in the affected skin.
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Registered trials
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