ArticleNeuromodulation : journal of the International Neuromodulation Society2020
Poststimulation Block of Pudendal Nerve Conduction by High-Frequency (kHz) Biphasic Stimulation in Cats.
Article in Neuromodulation : journal of the International Neuromodulation Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Ramped kilohertz-frequency signals produce nerve conduction block without onset response.Journal of neural engineering · 2025Article
- Temporal properties of transcutaneous direct current motor conduction block.Journal of neural engineering · 2025Article
- Pudendal Nerve Block by Adaptively Stepwise Increasing the Intensity of High-Frequency (10 kHz) Biphasic Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2025Article
- Model Analysis of Post-Stimulation Block of a Myelinated Axon by Direct Current.IEEE transactions on bio-medical engineering · 2023Article
- High frequency alternating current neurostimulation decreases nocifensive behavior in a disc herniation model of lumbar radiculopathy.Bioelectronic medicine · 2023Article
- Mechanisms Underlying Poststimulation Block Induced by High-Frequency Biphasic Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Intracellular sodium concentration and membrane potential oscillation in axonal conduction block induced by high-frequency biphasic stimulation.Journal of neural engineering · 2022Article
- High-frequency stimulation induces axonal conduction block without generating initial action potentials.Journal of computational neuroscience · 2022Article
- Model Analysis of Post-Stimulation Effect on Axonal Conduction and Block.IEEE transactions on bio-medical engineering · 2021Article
- Pudendal Nerve Block by Low-Frequency (≤1 kHz) Biphasic Electrical Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2021Article
- Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance.Scientific reports · 2021Article
- Quantitative comparisons of block thresholds and onset responses for charge-balanced kilohertz frequency waveforms.Journal of neural engineering · 2020Article
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo determine the relationship between various parameters of high-frequency biphasic stimulation (HFBS) and the recovery period of post-HFBS block of the pudendal nerve in cats. MATERIALS AND
methodsA tripolar cuff electrode was implanted on the pudendal nerve to deliver HFBS in ten cats. Two hook electrodes were placed central or distal to the cuff electrode to stimulate the pudendal nerve and induce contractions of external urethral sphincter (EUS). A catheter was inserted toward the distal urethra to slowly perfuse the urethra and record the back-up pressure generated by EUS contractions. After determining the block threshold (T), HFBS (6 or 10 kHz) of different durations (1, 5, 10, 20, 30 min) and intensities (1T or 2T) was used to produce the post-HFBS block.
resultsHFBS at 10 kHz and 1T intensity must be applied for at least 30 min to induce post-HFBS block. However, 10 kHz HFBS at a higher intensity (2T) elicited post-HFBS block after stimulation of only 10 min; and 10 kHz HFBS at 2T for 30 min induced a longer-lasting (1-3 h) post-HFBS block that fully recovered with time. HFBS of 5-min duration at 6 kHz produced a longer period (20.4 ± 2.1 min, p < 0.05, N = 5 cats) of post-HFBS block than HFBS at 10 kHz (9.5 ± 2.1 min).
conclusionHFBS of longer duration, higher intensity, and lower frequency can produce longer-lasting reversible post-HFBS block. This study is important for developing new methods to block nerve conduction by HFBS.
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