Evidence map›Paper›PMID 32839913›Full record

ReviewCurrent neurology and neuroscience reports2020

Neuromuscular Complications of Statin Therapy.

Elena Crisan, Vijaya K Patil

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

  1. Association Between Statin Initiation and Myasthenia Gravis Crisis.Journal of clinical neurology (Seoul, Korea) · 2026
    Article
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  11. Anti-HMGCR antibodies and asymptomatic hyperCKemia. A case report.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elena CrisanDepartment of Neurology, Edward Hines Jr VA Medical Center, 5000 S 5th Ave, Hines, IL, 60141, USA. elena.crisan2@va.gov.ORCID 0000-0002-6090-8956
Vijaya K PatilDepartment of Neurology, Edward Hines Jr VA Medical Center, 5000 S 5th Ave, Hines, IL, 60141, USA.
Loyola University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review provides an overview of neuromuscular side effects associated with statin use, their diagnosis, and treatment. RECENT

findingsThe discovery of anti-HMGCR antibodies led to a better understanding of clinical aspects of statin-associated anti-HMGCR myopathy and its treatment. Statins are widely prescribed medications with well-established benefits in the treatment of cardiovascular diseases and stroke. Adherence to statins is influenced by development of side effects, especially muscle related. There is wide range of neuromuscular side effects associated with statin therapy. Documented neuromuscular side effects include asymptomatic elevation of muscle enzymes, mild-moderate myalgias and cramps, toxic and immune-mediated severe necrotizing myopathy, and rare cases of rhabdomyolysis. In addition, statins can lead to unmasking or triggering of underlying muscle and neuromuscular junction disorders. This article identifies the risk factors and provides a review of neuromuscular side effects associated with statin use, their diagnosis and treatment.

Indexed as

Autoimmune DiseasesDrug-Related Side Effects and Adverse ReactionsHydroxymethylglutaryl-CoA Reductase InhibitorsMuscular DiseasesAutoantibodiesHumansAutoantibodiesHydroxymethylglutaryl-CoA Reductase InhibitorsAnti-HMGCR antibodiesAnti-HMGCR myopathyImmunosuppression therapyMuscle adverse eventsMyasthenia gravisNeuropathy

Identifiers

PMID32839913
OpenAlexW3081252303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.